摘要
Toll样受体5（TLR5）是一种模式识别受体,能够识别细菌的鞭毛蛋白,激活固有免疫,诱导下游一系列细胞因子的释放,是连接固有免疫和适应性免疫的桥梁.研究表明TLR5在一些感染性疾病的发生、发展中起到重要作用.本文总结并讨论了TLR5与感染性疾病发生发展的关系以及可能的致病机制.
Toll-like receptor 5 （TLR5） is one of the pattern recognition receptors and recognizes the flagellin protein of bacteria.It activates innate immune responses and induces production of a series of cytokines.TLR5 functions as a bridge linking innate and adaptive immunities.It is known that TLR5 plays an important role in the occurrence and development of certain infectious diseases.This review summarizes the relationships of TLR5 polymorphisms with the development of infectious diseases and discusses the possible pathogenesis.
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2017年第8期640-644,共5页
Chinese Journal of Microbiology and Immunology
基金
北京市自然科学基金（7142021）
北京市教委科研计划项目（KM201410025005）
