摘要
目的探究改进机械通气患者镇痛镇静疗法的措施与效果观察。方法从2017年1—5月选取80例机械通气患者,按随机数字表法分为观察组和对照组,每组40例。对照组给予常规镇痛镇静疗法,观察组采用改进的镇痛镇静疗法,比较两组患者6 h、12 h及48 h的平均动脉压、心率、呼吸频率、镇痛及镇静评分。统计两组患者镇静状态用量、机械通气时间、ICU停留时间及不良反应。结果观察组6小时心率、平均动脉压、呼吸频率、镇静评分及镇痛评分均低于对照组,差异具有统计学意义(P<0.05),其余时间各指标观察组与对照组对比,差异无统计学意义(P>0.05)。观察组达到镇静状态用量、机械通气时间及ICU停留时间低于对照组,差异具有统计学意义(P<0.05)。观察组不良反应的发生率如低血压、心动过缓及胃潴留低于对照组,差异具有统计学意义(P<0.05)。结论应用改进镇痛镇静疗法起效快,对血液动力学及血气值影响较小,可减少镇静药物的用量、减少机械通气的时间及重症监护室的治疗时间,并且减少不良反应的发生。
Objective To explore the measures and effects of sedative and sedative treatment for patients with mechanical ventilation. Methods From January to May 2017, 80 patients with mechanical ventilation were selected, they were divided into observation group and control group by random number table, 40 cases in each group. Control group was treated with routine analgesia and sedative therapy, observation group was treated with improved sedative and analgesic therapy, mean arterial pressure, heart rate, respiratory rate, analgesia and sedation scores for 6 hours, 12 hours and 48 hours between the two groups were compared. The sedation status, dosage, mechanical ventilation time, ICU residence time and adverse reactions between the two groups were observed. Results The heart rate, mean arterial pressure, respiratory rate, sedation score and analgesic score in the observation group were lower than those in the control group at 6 hours, the difference was statistically significant （P 〈 0.05）, there was no significant difference between the observation group and the control group in the rest time （P 〉 0.05）. The reached sedation dosage, mechanical ventilation time and ICU retention time in observation group was lower than the control group, the difference was statistically significant （P 〈 0.05）. The incidence of adverse reactions in the observation group, such as hypotension, bradycardia and gastric retention, was lower than that of the control group, the difference was statistically significant （P 〈 0.05）. Conclusion Tile applicatiou of improved analgesia and sedation therapy effect is fast, and has less effect on the value of hemodynamics and blood gas, can reduce the dosage of sedative drugs, tile time of mechanical ventilation in ICU treatment time, and tile occurrence of adverse reactions.
出处
《中国卫生标准管理》
2017年第20期129-131,共3页
China Health Standard Management
基金
上海市浦东新区卫生系统学科带头人培养计划(PDWRd2013-11)
关键词
重症监护室
右美托咪定
镇痛
镇静
临床疗效
intensive care unit
dexmedetomidine
analgesia
sedation
clinical efficacy
