摘要
脊髓损伤是临床上一种常见的损伤,虽然其治疗已经取得了巨大的进步,但预后并不佳,只有极少数患者的神经功能达到完全修复。间充质干细胞是一种干细胞,具有多向分化潜能,来源丰富,具有活性高、免疫原性低的特点,易于分离、培养、扩增,在体外长期培养过程中始终保持多向分化的潜能,遗传背景稳定。间充质干细胞的自体和异体移植对脊髓损伤的修复均具有一定的效果,其作用机制可能与间充质干细胞减轻炎症和氧化应激反应、填充替代作用、神经营养作用以及抑制免疫反应、促进轴突再生等有关。
Spinal cord injury is a common injury in clinic,although great progress has been made in its treatment,the prognosis is poor and only a small number of patients have complete neurological repair. Mesenehymal stem cell is a kind of stem cell has the potential of multi-directional differentiation, rich source, high activity, weak immunogenicity, easy isolation, cultivation and amplification. Among the long-term culture in vitro, it can maintaine the potential of muhilineage differentia- tion ,the genetic background is stable. Mesenehymal stem cellst autologous and ailogeneie transplantation have certain effect on the repair of spinal eord injury,the mechanism may be related to mesenchymal stem ceils reduce the inflammation and oxidative stress, the filling replacement effect, neurotrophie effect, and inhibit the immune response, promote axon regenera- tion and so on.
作者
肖仁顺
蒋星海
阮宏
吴凯
宋玉林
XIAO Renshun JlANG Xinghai RUAN Hong WU Kai SONG Yulin.(Department of Orthopaedics, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, Chin)
出处
《医学综述》
2017年第18期3542-3545,3550,共5页
Medical Recapitulate
基金
国家自然科学基金(81360271
30801158)
南昌大学研究生创新专项资金(cx2016326)
江西省教育厅课题(GJJ14054)
江西省自然科学基金(20151BAB205051)
关键词
脊髓损伤
间充质干细胞
干细胞移植
Spinal cord injury
Mesenchymal stem cell
Cells transplantation
