摘要
单纯疱疹病毒性角膜炎（herpes simplex keratitis,HSK）是由单纯疱疹病毒Ⅰ型（herpessimplex virus type Ⅰ,HSV-1）感染引起的具有高复发率、高致盲率及难根治性特点的疾病,可导致角膜溶解、新生血管形成及溃疡穿孔,是目前角膜病中最常见的致盲眼病之一.本文参考目前国内外实验研究时使用的各种HSK动物模型建模方法来进行综述,如建立原发感染模型的划痕法、环钻法、外植体培养法以及潜伏感染模型和诱导复发模型的建立方法.力求探索如何建立一种可靠的HSK动物模型,在为研究人类HSK发病机制、药物治疗和对比以及角膜移植等方面均有重要意义.
Herpes simplex keratitis （HSK） is resulted from Herpes simplex virus type Ⅰ （HSV-1）,which features a high reoccurrence,high blindness incidence and incurability and is likely to lead to the dissolving of cornea,the formation of new vessels,and even perforating ulcer,being one of the cornea-related diseases that is deemed as the toughest one in both international and domestic relevant domains.Therefore,this paper reviews the processing methods of animal model targeting at the Herpes simplex keratitis of our country and foreign countries so far,such as primary infection model （include scratching method,trepanation and explants）,latent infection pattem and recurrent infection model.A reliable nominal model is desperately needed to conduct further study in areas such as the mechanisms of HSK,medical treatment,and the transplantation of cornea.
出处
《国际眼科纵览》
2017年第3期204-209,共6页
International Review of Ophthalmology
基金
国家自然科学基金（81260145
81560159）
教育部留学回国人员科研启动基金
留学人员科技活动项目择优资助经费
云南省教育厅科学研究基金项目（2012Y016）
