摘要
目的研究降钙素原及T细胞亚群对急性脑梗死后感染的诊断价值。方法选取2015年2月至2016年1月在该院进行诊治的急性脑梗死患者122例,根据患者脑梗死后是否发生感染分为感染组(60例)和未感染组(62例)。分别对比两组入院时收缩压、舒张压、体温、美国国立卫生研究所卒中量表(NIHSS)评分,以及脑梗死发生部位,降钙素原、CD4、CD8水平,并进行Logistic回归分析。结果感染组NIHSS评分为(14.9±5.7)分,明显高于未感染组的(10.6±3.8)分(P<0.01)。感染组脑桥梗死人数占比为35.48%,明显高于未感染组的17.74%(P<0.05)。感染组降钙素原明显高于未感染组,而CD4、CD8水平则明显低于未感染组(P<0.05)。经多因素Logistic回归分析,影响急性脑梗死后感染的危险因素包括脑桥梗死、NIHSS评分、降钙素原、CD4及CD8水平。结论临床工作中通过对急性脑梗死患者的降钙素原与T细胞压群进行检查,有利于预测感染的发生。
Objective To study the diagnostic value of procalcitonin and T cell subsets in infection after acute cerebral infarc- tion（ACI）. Methods One hundred and twenty-two patients with ACI in our hospital from February 2015 to January 2016 were se- lected and divided into the infection group（60 cases） and non-infection group（62 cases） according to whether infection occurring. The systolic blood pressure, diastolic blood pressure, body temperature, NIHSS score, cerebral infarction location, procalcitonin, CD4 level,CD8 level were compared between the two groups. The Logistic regression analysis was performed. Results The NIHSS score in the infection group was （14.9±5.7） points,which was significantly higher than （10.6±3.8） points in the non-infection group, the differences were statistically significant （P〈0.05）. The number of pons infarction in the infection group accounted for 35.48 〈 （22/60）, which was significantly higher than 17.74 % （11/62） in the non-infection group, the differences were statistically significant（P〈0.05）. The procalcitoninl level in the infection group was significantly higher than that in the non-infection group, while the levels of CD4 and CD8 were significantly lower than those in the non-infection group, the differences were statistically sig- nificant （P〈0.05）. The multivariate Logistic regression analysis showed that the risk factors affecting infection after cerebral in- farction included pons infarction,NIHSS score, procalcitonin,CD4 and CD8 levels. Conclusion Detecting procalcitonin and T cell subsets in the patients with ACI in clinical work is conducive to predict the infection occurrence.
出处
《重庆医学》
CAS
北大核心
2017年第26期3644-3645,3648,共3页
Chongqing medicine
关键词
降钙素
T淋巴细胞亚群
急性病
脑梗死
抗原
CD4
抗原
CD8
感染
calcitonin ； T-lymphocyte subsets
acute disease ； brain infarction
antigens, CD4 ； antigens, CD8 ； infection
