摘要
目的观察平肝健脾法治疗肝郁脾虚证抑郁障碍的临床疗效。方法将150例抑郁障碍病人随机分为3组:西药组、中药组及中西医结合组,各50例。西药组给予盐酸舍曲林口服;中药组给予平肝健脾法汤剂治疗,中西医结合组给予盐酸舍曲林联合平肝健脾法汤剂治疗。3组疗程均为3个月。观察3组临床疗效,治疗前后汉密尔顿抑郁量表(HAMD)评分、中医证候量表评分变化。结果 3组病人治疗后HAMD评分、中医证候量表评分显著低于治疗前(P<0.05);治疗第2个月、第3个月,中药组病人HAMD、中医证候量表评分均显著低于西药组(P<0.05);治疗后第1个月、2个月、3个月,中西医联合组病人HAMD、中医证候量表评分均显著低于中药组(P<0.05或P<0.01)。结论平肝健脾法联合盐酸舍曲林治疗抑郁障碍疗效显著,无明显毒副作用,提示中医辨证治疗抑郁障碍具有一定的优势。
Objective To observe the clinical efficacy of the therapy of soothing liver and invigorating spleen for the treatment of depression with liver-qi stagnation and spleen-deficiency syndrome type.Methods One hundred and fifty patients with depression and liver-qi stagnation and spleen-deficiency syndrome type were randomly divided into three groups：western medicine treatment group（group A,n =50）treated with sertraline hydrochloride,traditional Chinese medicine（TCM）treatment group（group B,n =50）treated with the therapy of soothing liver and invigorating spleen decoction,and combine the traditional Chinese and western medicine treatment group（group C,n =50）treated with sertraline hydrochloride and the therapy of soothing liver and invigorating spleen decoction.Three treatment course lasted for3 months.The clinical efficacy was assessed with Hamilton Depression Rating Scale（HAMD）,Symptom Rating Scale of TCM.Results The scores of HAMD and Symptom Rating Scale of TCM in three groups after treatment were significantly lower than those before treatment（P〈0.05）.The scores of HAMD and Symptom Rating Scale of TCM in group B were significantly lower than those in group A after treatment of 2 months and 3 months（P〈0.05 or P〈0.01）.The scores of HAMD and Symptom Rating Scale of TCM in group C were significantly lower than those in group B after treatment of 1months,2 months and 3 months（P〈0.05 or P〈0.01）.Conclusion Combined with the therapy of soothing liver and invigorating spleen and sertraline hydrochloride has a better curative effect on depression with liver-qi stagnation and spleendeficiency syndrome type,which indicates that Chinese medicine has an advantage in the treatment of depression.
出处
《中西医结合心脑血管病杂志》
2017年第16期2048-2050,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
上海市卫生和计划生育委员会中医药科研基金项目(No.2014LP031A)
浦东新区卫生和计划生育委员会基金项目(No.PW2016B-7)
关键词
抑郁障碍
肝郁脾虚证
平肝健脾法
盐酸舍曲林
中医证候
郁证
depression
liver-qi stagnat ion and spleen deficiency syndrome type
the therapy of soothing liver and invigorating spleen
sertraline hydrochloride
traditional Chinese medicine syndrome
depression syndrome
