摘要
目的:探讨西酞普兰与阿米替林治疗老年抑郁症的疗效与安全性。方法:将44例符合《中国精神障碍分类与诊断标准(第3版)》(CCMD-3)诊断标准的老年抑郁症患者随机分成两组,分别给予西酞普兰和阿米替林治疗6周。采用汉密顿抑郁量表(HAMD)和副反应量表(TESS)评定疗效和副反应。结果:西酞普兰组显效率为86%,阿米替林组显效率为82%,两者疗效相比差异无显著性意义(χ2=0.17,P>0.05),但西酞普兰起效快于阿米替林。西酞普兰组的副反应明显较阿米替林组轻。结论:西酞普兰治疗老年抑郁症起效快,副反应轻,安全有效。
AIM:To explore the efficacy and safety of citalopram and amitrptyline in treating depression of elderly patients. METHODS:A total of 44 elderly patients with depression,who were in accordance with the diagnostic criteria of Chinese Classification of Mental Disorders(third edition,CCMD 3),were randomly assigned into two groups,and treated with citalopram and amitrpyline for 6 weeks respectively.Hamilton rating scale for depression(HAMD) and treatment emergent symptom scale(TESS) were used to evaluate the efficacy and side effects. RESULTS:The effective rates were 86%in the citalopram group and 82%in the amitripyline group,and there was no significant difference between the two group after treatment(χ2=0.17,P >0.05).The effectual time in the citalopram group was remarkably quicker than that in the amitrpyline group.Side effects in the citalopram group were obviously fewer than those in the amitriptyline group. CONCLUSION:Citalopram is safe,effective and take into effect fast with fewer side effects for the treatment of senile depression.
出处
《中国临床康复》
CSCD
2004年第27期5762-5763,共2页
Chinese Journal of Clinical Rehabilitation
