摘要
目的探讨呼出气一氧化氮（FeNO）在慢性咳嗽严重程度评估中的临床价值。方法根据我院呼吸内科门诊2014年6月至2015年2月明确诊断为慢性咳嗽的连续病例68例，对所有患者根据FeNO水平分组，研究组间主观评分差异，并在治疗4周后进行FeNO检测、并评价咳嗽症状积分、莱赛斯特生活质量问卷（LCQ）评分。结果以FeNO水平分组后，患者LCQ评分及咳嗽症状日间积分各组间差异有统计学意义（P〈O．01）。将患者根据咳嗽病因分组，咳嗽变异性哮喘（CVA）组FeNO均值[（67．5±17．1）ppb]显著高于EB组[（34．6±9）ppb]，2组高于其他病因组[（23．4±8．9）ppb]（Z=-4．9，P〈O．01），治疗后FeNO水平、LCQ值和咳嗽积分相较治疗前均有改善（Z=-3．975，P〈0．01），3组病因间FeNO下降程度不同（P〈O．01），CVA组平均改善率[（33．2±3．9）％]高于其他2组病因患者，FeNO治疗前后总体下降变化与LCQ评分（r=0．48，P〈0．01）及咳嗽症状积分变化呈正相关，其中CVA组及EB组与LCQ评分治疗变化呈较强的相关性，相关系数分别为0．55和0．66（P〈0．01）。结论FeNO与患者的咳嗽症状和生活质量存在相关性，在慢性咳嗽病情评估中具有重要参考价值。
Objective To evaluate the values of fractional exhaled nitric oxide（FeNO） in assessing the severity of chronic cough. Methods Totally 68 patients with chronic cough were recruited from Department of Resplrarory Medicine from June 2014 to February 2015. All patients are grouped according to the FeNO levels, the differences of leicester cough questionnaire （LCQ） and cough symptom scores among groups are evaluated, FeNO tests, LCQ and cough symptom scores before and after treatment for 4 weeks are recorded. Results LCQ and daytime cough symptom score showed significant differences among groups according to FeNO levels （P 〈0.01）. There was significant difference in FeNO levels among 3 groups [cough variant asthma （CVA）, eosinophilic bronchitis fEB）, other causes], those with CVA [（67.5± 17.1） ppb] or EB[（34.6± 9） ppb] had a significantly higher median FeNO level than those with other etiology [（23.4±8.9） ppb],and CVA were also higher than EB （Z =-4.9, P 〈0.01）, FeNO levels, LCQ scores and cough symptom scores all showed significant improvements After 4 weeks treatment （Z =-3. 975, P 〈0.01）, significant differences in the improvements rates were noticed among three groups in which CVA group showed the highest rate （33.2 ±3.9） %. On the whole, there were significant correlations between the change of FeNO decrease and the increase of LCQ （ r =0.48, P 〈 0.01） especiallyinCVA（r=0.55, P〈0.01） andEB（r-0.66, P〈0.01） groups. Conclusions FeNO showed a important value in the evaluation of chronic cough symptom severity base on our finding that FeNO decrease is correlated with the improvement of life quality score and cough symptom score.
出处
《国际呼吸杂志》
2017年第16期1233-1238,共6页
International Journal of Respiration
