摘要
目的 探讨呼出气一氧化氮（FeNO）检测在临床对慢性咳嗽患者的诊断意义.方法 选择2012年8月～2013年5月在本院就诊的慢性咳嗽患者80例,对80例患者实施FeNO检测和支气管激发试验,分析FeNO检测法对诊断咳嗽变异性哮喘（CVA）的最佳值及对非CVA患者诊断为嗜酸粒细胞性支气管炎（EB）的最佳临界值.结果 80例患者中CVA有35例,EB患者有28例,其他慢性咳嗽患者17例.CVA患者的FeNO值明显高于其他慢性咳嗽的患者,EB患者FeNO值要高于除CVA患者的其他慢性咳嗽患者,差异有统计学意义（P＜0.05）.根据ROC曲线FeNO诊断CVA敏感度为79.6％,特异度为94％,应用FeNO诊断EB的敏感度为70％,特异度为90％.结论 慢性咳嗽患者病因不同,FeNO的水平也不相同,因此临床可以根据FENO的值来诊断患者咳嗽的病因.
Objective To explore the diagnostic significance of fractional exhaled nitric oxide （FeNO） test in patients with chronic cough in clinic.Methods 80 patients with chronic cough come to see doctors in our hospital from August 2012 to May 2013 were selected.They were carried out FeNO test and bronchial provocation test in order to analyze the optimum value for diagnosing cough variant asthma （CVA） by FeNO method and the optimal threshold for diagnos- ing eosinophilic bronchitis （EB） in non-CVA patients.Results Among 80 patients,there were CVA in 35 cases,EB in 28 cases and other chronic cough in 17 cases.The value of FeNO in CVA patients was obviously higher than that of the others.The value of FeNO in EB patients was higher than that of patients with other chronic cough except CVA patients,was statistical difference （P〈0.05）.According to the ROC curve,the sensitivity of CVA diagnosed by FeNO was 79.6%,and the specificity was 94%.The sensitivity of EB by FeNO test was 70%,and the specificity was 90%.Conclu- sion Due to different causes of chronic cough,the FeNO levels are not the same.Therefore,the value of FeNO can be se- lected to diagnose cause of cough in clinic.
出处
《中国当代医药》
2013年第29期42-43,45,共3页
China Modern Medicine
