摘要
缺血性心律失常是最常见的循环系统疾病之一,它可单独发病亦可与其他心血管疾病伴发,目前其发病率不断增加。缺血性心律失常曾被认为是由心肌细胞的兴奋性异常引起,近年来逐渐考虑为心肌细胞超微结构被破坏、心功能受损的结果。缝隙连接蛋白43(Cx43)是心室缝隙连接通道的主要构成成分,其分布和表达异常可导致心肌细胞间传导速度减慢和传导各向异性发生改变,最终发生折返性心律失常,这提示Cx43很可能成为心律失常治疗的新靶点。
Ischemic arrhythmia is one of the most common diseases of the circulatory system. It can occur alone or simultaneously with other cardiovascular diseases. The incidence of the diseases is currently growing. Ischemic arrhythmia, once thought to be caused by abnormal excitability of cardiomyocytes, has been gradually considered as a result of damage to the uhrastructure of cardiac myocytes and impaired cardiac function in recent years. Connexin43 （ Cx43 ） is the major component of the ventricular GJ channels, and its abnormal expression and distribution will lead to the abnormality of the conduction of the cardiomyocytes,decreasing the conduction velocity and changing the anisotropy, producing reentrant arrhythmia, which suggests that Cx43 may become a new target for the treatment of arrhythmia.
出处
《医学综述》
2017年第17期3368-3372,共5页
Medical Recapitulate
基金
国家自然科学基金(81660057)
