摘要
目的:探讨参芪地黄汤加减联合西药治疗高血压肾病的疗效。方法:根据随机数字表法将2012年1月—2016年7月本院收治的180例高血压肾病患者分为对照组(90例)与观察组(90例),对照组患者接受硝苯地平联合卡托普利治疗,观察组患者在硝苯地平、卡托普利基础上再联合使用参芪地黄汤,现对比分析两组患者的治疗效果。结果:(1)组内不同时间点之间的血压比较:治疗前、治疗1个月后、治疗3个月后,观察组与对照组3个时间点之间的舒张压(DBP)、收缩压(SBP)比较差异均有统计学意义(P<0.05),治疗前的DBP、SBP均显著高于治疗1个月后、治疗3个月后(P<0.05),治疗1个月后的DBP、SBP均显著高于治疗3个月后(P<0.05)。(2)组内不同时间点之间的肾功能指标比较:治疗前、治疗1个月后、治疗3个月后,观察组与对照组3个时间点之间的血清胱抑素C(SCys C)、估算肾小球滤过率(eGFR)、尿微量白蛋白(Um Alb)相比差异均有统计学意义(P<0.05);治疗前的SCys C、Um Alb显著高于治疗1个月后、治疗3个月后(P<0.05),eGFR显著低于治疗1个月后、治疗3个月后(P<0.05);治疗1个月后的SCys C、Um Alb显著高于治疗3个月后(P<0.05),eGFR显著低于治疗3个月后(P<0.05)。不同时间点两组之间肾功能指标比较:治疗前,两组患者SCys C、eGFR、Um Alb相比差异均无统计学意义(P>0.05);治疗1个月后、治疗3个月后,观察组SCys C、Um Alb显著低于对照组,eGFR均显著高于对照组,差异均有统计学意义(P<0.05)。结论:参芪地黄汤加减联合西药治疗高血压肾病的疗效确切,在控制血压的同时有效保护患者肾功能,值得临床推广应用。
Objective： To investigate the therapeutic effect of Shenqi Dihuang Decoction combined with western medicine in the treatment of hypertensive nephropathy. Methods： Methods： According to the random number table method,180 cases of patients with hypertensive nephropathy in January 2012-July 2016 in our hospital were divided into control group（ 90 cases） and observation group（ 90 cases）. The control group received nifedipine combined with captopril. The patients in the observation group on the basis combined with Shenqi Dihuang Decoction. Analyze the therapeutic effect of two groups. Results： The results between different time points within the group compared to the blood pressure： 1 and 3 months after treatment,the observation and the control groups＇ diastolic blood pressure（ DBP） and systolic blood pressure（ SBP） showed no significant differences（ P〈0. 05）. Before treatment,DBP and SBP were significantly higher than that 1 and 3 months after treatment（ P〈0. 05）. 1 month after treatment,DBP and SBP were significantly higher than that 3 months after treatment（ P〈0. 05）. Comparison of renal function indexes between different time points： 1 and 3 months after treatment,the observation and the control groups＇ serum cystatin C（ SCys C）,estimated glomerular filtration rate（ eGFR） and urinary albumin（ Um Alb） were statistically significant（ P〈0. 05）. SCys C and Um Alb before treatment were significantly higher than that 1 and 3 months after treatment（ P〈0. 05） and eGFR was significantly lower than that 1 and 3 months after treatment（ P〈0. 05）. 1 month after treatment,SCys C and Um Alb were significantly higher than that 3 months after treatment（ P〈0. 05） and eGFR was significantly lower than that 3 months after treatment（ P〈0. 05）.Comparison of different time points between the two groups of renal function indexes： before treatment,two groups＇ SCys C,eGFR and Um Alb were not statistically significant（ P〈0. 05）. 1 and 3 mon
出处
《辽宁中医杂志》
CAS
北大核心
2017年第8期1697-1699,共3页
Liaoning Journal of Traditional Chinese Medicine
关键词
参芪地黄汤
硝苯地平
卡托普利
高血压肾病
Shenqi Dihuang Decoction
nifedipine
captopril
hypertensive nephropathy
