摘要
目的探讨新辅助化疗对子宫内膜癌患者血清尾型同源盒转录因子-2(CDX-2)、Dickkopf(DKK)蛋白家族中的DKK-3、人第10号染色体缺失的磷酸酶(PTEN)的影响,及在改善患者术后复发、生存期中的价值。方法选取2012年3月至2015年3月收治的112例子宫内膜癌患者,按照随机抽签法将患者分为研究组(n=56)及对照组(n=56)。对照组患者实施常规术后化疗,研究组术前采用新辅助化疗,术后实施常规化疗。比较分析两组治疗前及治疗后血清CDX-2、Dkk-3及PTEN变化,并观察两组不良反应的发生情况,分析术后2年两组复发人数与生存情况。结果治疗后,研究组患者血清CDX-2、Dkk-3及PTEN水平均明显低于对照组(P<0.05)。术后2年,两组患者全部生存,生存率均为100.0%。研究组术后复发率为12.5%,明显低于对照组术后复发率26.8%(P<0.05)。研究组治疗期间不良反应发生率为39.3%,明显低于对照组不良反应发生率66.1%(P<0.05)。结论子宫内膜癌患者实施新辅助化疗效果显著,能够有效降低患者血清CDX-2、Dkk-3及PTEN水平,降低术后复发率,提高患者生存期,不良反应少,值得临床推广应用。
Objective To investigate the effect of neoadjuvant chemotherapy on endometrial cancer patients with caudal type homeobox transcription factor 2 （CDX -2） , Dickkopf （DKK） protein phosphatase family DKK- 3, chromosome tenth deletion （PTEN） effect, and recur- rence, whether or not helping improve the postoperative survival rate. Methods 112 patients with endometrial carcinoma from March 2012 to March 2015 were randomly divided into study group （n = 56） and control group （n = 56）. The study group receive neoadjuvant chemotherapy. Comparative analysis of changes of serum CDX - 2, Dkk - 3 and PTEN in the two groups before and after treatment was performed. The occurrence of adverse reactions of two groups was compared. The postoperative 2 years survival and the number of patients in the two groups was compared. Results After treatment, the serum CDX - 2, Dkk - 3 and PTEN of study group patients were significantly lower than control group （ P 〈 0.05 ）. All the patients in the two groups survived, the survival rate was 100%. The recurrence rate of the study group was 12.5%, which was lower than control group 26.8% （ P 〈 0.05 ）. The incidence of adverse reactions in the treatment group was 39.3 % , which was lower than control group 66.1% （ P 〈 0.05 ）, and the incidence of adverse reactions was significantly lower than that in the control group （ P 〈 0.05 ）. Conclusion The patients with endometrial cancer after implementing the neoadjuvant chemotherapy showed good effect, can effectively reduce the serum CDX - 2, Dkk - 3 and PTEN levels of patients, reduce the postoperative recurrence rate and improve survival rate, had less side effects. This method is wor- thy of application and promotion.
出处
《临床和实验医学杂志》
2017年第17期1739-1742,共4页
Journal of Clinical and Experimental Medicine
