摘要
目的比较奥氮平与利培酮对老年期精神障碍患者的临床效果和生活质量的影响。方法选取2013年6月至2015年6月在我院精神科接受治疗的老年期精神障碍患者共80例,随机分成奥氮平组和利培酮组,分别使用奥氮平和利培酮进行治疗,采用阳性与阴性症状量表(PANSS)、不良反应量表(TESS)、生活质量综合评定问卷(GQOLI)分别评定患者的疗效、不良反应及生活质量。结果与治疗前相比较,两组患者的物质生活、躯体功能、心理功能、社会功能以及总分均明显升高(P<0.05)。奥氮平组的物质生活、躯体功能、心理功能、社会功能以及总分明显高于利培酮组(P<0.05)。奥氮平组的兴奋或者激越,睡眠障碍,肌强直,震颤,静坐不能,恶心呕吐,头晕头痛,心动过速,肝功能受损,TESS评分均明显低于利培酮组(P<0.05)。两组患者治疗后PANSS总分均下降,但两组之间没有明显差异。结论与利培酮相比较,奥氮平在治疗老年期精神障碍疾病方面临床效果更好,安全性更高,改善生活质量,值得在临床上推广应用。
Objective This study was designed to compare the efficacy and safety of olanzapine and risperidone in senile patients with mental health disorders. Methods 80 elderly patients with psychiatric disorders were randomly divided into olanzapine group and risperidone group. Positive and negative syndrome scale（PANSS）,Adverse Reaction Scale（TESS）,and Quality of Life Questionnaire（GQOLI）were used to evaluate the efficacy,adverse reactions and quality of life of the patients respectively. Results Compared with pre-treatment,the physical,physical,psychological,social function and total scores of the two groups were significantly increased after 6 months of treatment（P〈0.05）. After 6 months of treatment,the physical,psychological,social function and total score in olanzapine group were significantly higher than those in risperidone group（P〈0.05）. Nausea,vomiting,dizziness,headache,tachycardia,abnormal liver function and TESS in olanzapine group were significantly lower than those in risperidone group（P〈0.05）. After treatment,the PANSS scores in both group were decrease,there were no significant differences between two groups. Conclusion Compared with risperidone,olanzapine has better efficacy and safety in senile patients with psychiatric disorders.
出处
《国际精神病学杂志》
2017年第4期619-621,共3页
Journal Of International Psychiatry
关键词
精神障碍
奥氮平
利培酮
Mental disorders
Olanzapine
Risperidone
