摘要
目的 分析丙泊酚对急性颅脑损伤手术患者的脑保护作用.方法 选取2014年6月至2016年6月急性颅脑损伤患者90例,随机分为两组,每组45例.对照组给予异氟醚麻醉,观察组给予丙泊酚麻醉.比较两组颅内压、脑氧分压、初醒时间、6个月后MMSE随访评分.结果 麻醉前,颅内压、脑氧分压两组比较差异未见统计学意义（P〉0.05）.麻醉后,对照组术中颅内压、术后2 h的颅内压及脑氧分压、初醒时间少于观察组,差异有统计学意义（P〈0.05）.结论 丙泊酚可以控制颅内压升高,增加脑内氧含量,增高脑氧分压,保护脑组织,改善患者术后精神状态.
Objective To analyze the neuro-protective effect of propofol on surgical patients with acute craniocerebral injury.Methods Ninety patients with acute craniocerebral injury were selected from June 2014 to June 2016, and were randomly divided into the two groups, with 45 cases in each group.The control group was treated with isoflurane anesthesia, and the observation group was given propofol anesthesia.The intra cranial pressure （ICP）, cerebral oxygen partial pressure, wake up early time, MMSE follow-up score after 6 months were compared between the two groups.Results Before anesthesia, ICP, cerebral oxygen partial pressure were compared between the two groups, the differences were not significant （P〉0.05）.After anesthesia, after operation （ICP）, postoperative 2 h （ICP）,intraoperative （cerebral oxygen partial pressure）, postoperative 2 h （cerebral oxygen partial pressure）, postoperative follow-up MMSE score of the control group were lower than those of the observation, the differences were significant （P〈0.05）.Conclusions Propofol can control the increase of intracranial pressure, increase the oxygen content in brain and cerebral oxygen partial pressure, protect the brain tissue, and improve the postoperative mental state.
出处
《中国实用医刊》
2017年第15期52-54,共3页
Chinese Journal of Practical Medicine
关键词
颅脑损伤
异丙酚
异氟醚
Craniocerebral injury
Propofol
Isoflurane
