摘要
目的评价国产Sabin株脊髓灰质炎(脊灰)灭活疫苗(Inactivated poliomyelitis vaccine,IPV)接种后的安全性,为中国脊灰疫苗免疫策略的调整提供依据。方法采用主动监测方法于2015年9月-2016年2月收集宁夏回族自治区同心县所有适龄儿童接种国产Sabin株IPV和三价脊灰减毒活疫苗(t OPV)后的不良反应,采取被动监测方法通过中国免疫规划信息管理系统收集2008-2016年宁夏全区国产Sabin株IPV、t OPV及其他免疫规划(EPI)疫苗的不良反应数据,比较分析不良反应发生率。结果主动监测显示接种国产IPV、t OPV后的一般反应发生率分别为2 464.33/10万剂、64.92/10万剂。被动监测显示,接种国产IPV的一般反应、异常反应发生率分别为51.68/10万剂、1.67/10万剂;接种t OPV后的一般反应、异常反应发生率分别为1.73/10万剂、0.22/10万剂。与其他EPI疫苗相比,国产IPV一般反应发生率最高,但其异常反应发生率低于麻疹减毒活疫苗、白喉破伤风联合疫苗、麻腮风联合减毒活疫苗、麻疹风疹联合减毒活疫苗和卡介苗,且无严重异常反应发生。结论接种国产Sabin株IPV安全性良好;主动监测的灵敏性高于被动监测。
Objective To evaluate the safety of domestic Sabin strain inactivated poliovirus vaccine（IPV）,and provide evidence to adjust the polio immunization strategy in China. Methods Active surveillance was used to collect adverse reactions of IPV and trivalent poliomyelitis attenuated live vaccine（t OPV） among eligible children in Tongxin county of Ningxia from September 2015 to February 2016,and passive surveillance was used to collect adverse reactions of IPV,t OPV and other vaccines in the Expanded Program on Immunization（EPI） from 2008 to 2016 in Ningxia through the China Immunization Program Information Management System. The rates of adverse reactions were compared. Results Active surveillance showed that the rates of common reactions for domestic IPV and t OPV were 2 464. 33 and 64. 92 per 100 000 doses,respectively. Passive surveillance showed that the respective rates of common reactions and rare reactions were 51. 68 and 1. 67 per 100 000 doses for domestic IPV,and 1. 73 and 0. 22 per 100 000 doses for t OPV. The rate of common reactions for domestic IPV was higher than for other EPI vaccines,but the rate of rare reactions for domestic IPV was lower than that for measles vaccine,diphtheria and tetanus combined vaccine,measles,mumps and rubella combined attenuated live vaccine,measles and rubella combined attenuated live vaccine,and Bacillus Calmette-Guerin vaccine;no serious adverse reactions were seen. Conclusions The safety of domestic Sabin strain IPV was good.The sensitivity of active surveillance was higher than that of passive surveillance.
出处
《中国疫苗和免疫》
北大核心
2017年第4期383-386,共4页
Chinese Journal of Vaccines and Immunization
