摘要
目的·评价冠状动脉钙化积分(CaCS)与腹膜透析患者预后的相关性。方法·选择透析龄2个月以上的临床状况稳定的腹膜透析患者,采用多层螺旋计算机断层扫描检测CaCS,按CaCS的分值将患者分为无钙化组、低分钙化组和高分钙化组,比较3组患者的基本资料和终点事件(包括全因死亡、心血管事件和心血管死亡)发生率,分析CaCS与终点事件的相关性。结果·共入选254名患者,其中男性132名,平均年龄(62.9±15.0)岁;其中无钙化组93例,低分钙化组105例,高分钙化组56例。与无钙化组相比,CaCS较高的患者年龄更大,舒张压、残余肾功能和血清白蛋白更低,糖化血红蛋白和血清胰岛素水平更高。多因素Cox回归分析显示,在腹膜透析患者中CaCS是所有终点事件的独立的危险因素。结论·CaCS是腹膜透析患者全因死亡、心血管事件和心血管死亡的独立危险因素。
Objective · To estimate correlation between coronary artery calcification score （CaCS） and prognosis of peritoneal dialysis （PD） patients. Methods · The clinically stable patients who had undergone PD for at least 2 months were recruited for this prospective and observational cohort study. Coronary artery calcification was assessed by multislice spiral computed tomography and was recorded according to the Agatston score. The patients were assigned to 3 groups, i.e. no calcification group （CaCS=0）, low calcification group （0〈CaCS〈400） and high calcification group （CaCS ≥ 400）, to compare their basic data and endpoint events （including all-cause mortality, cardiovascular events and cardiovascular mortality）. And then the correlation between CaCS and endpoint events was analyzed. Results · A total of 254 PD patients （including 132 males） with a mean age of （62.9±15.0） years were recruited for this study. There were 93, 105, and 56 cases in no calcification group, low calcification group and high calcification group, respectively. Compared with no calcification group, patients with higher CaCS were older, had lower diastolic blood pressure, residual renal function, and serum albumin, and had higher glycosylated hemoglobin and serum insulin. Multivariate Cox regression revealed that CaCS was an independent risk factor for all the three endpoint events in PD patients. Conclusion · CaCS was an independent predictor of all-cause mortality, cardiovascular events and cardiovascular mortality in PD patients.
出处
《上海交通大学学报（医学版）》
CSCD
北大核心
2017年第8期1120-1126,共7页
Journal of Shanghai Jiao tong University:Medical Science
基金
宝山区卫生青年医学人才培养计划(bswsyq-2015-A06)~~
关键词
冠状动脉钙化积分
腹膜透析
预后
心血管事件
危险因素
coronary artery calcification score
peritoneal dialysis
prognosis
cardiovascular event
risk factor
