摘要
目的对三联疗法联合益生菌治疗小儿幽门螺杆菌(Hp)相关性胃炎的临床效果进行分析。方法选取泉州医学高等专科学校附属人民医院儿科门诊自2014年7月至2015年7月收治的90例Hp相关性胃炎患儿,采取随机数字表法分为对照组与观察组,每组各45例。对照组给予标准的三联疗法,观察组在对照组基础上加用益生菌,对比两组临床疗效、不良反应及随访1年的复发率。结果观察组与对照组相比临床总有效率较高,差异具有统计学意义(χ~2=5.69,P<0.05)。两组治疗后与治疗前相比,上腹部疼痛、上腹部胀气、反酸、嗳气评分均降低(t=5.67~9.33,均P<0.05),观察组治疗后与对照组治疗后相比上述评分比较差异均具有统计学意义(t=7.03~8.11,均P<0.05)。观察组与对照组相比恶心呕吐、头晕、嗜睡、随访1年复发率均较低,差异均具有统计学意义(χ~2值分别为5.89、6.33、6.25、5.69,均P<0.05)。结论三联疗法联合益生菌治疗小儿Hp相关性胃炎的临床效果显著,不良反应发生率较低,随访未见复发。
Objective To analyze the clinical effect of triple therapy combined with probiotics treatment on helicobacter pylori（ Hp）associated gastritis in children. Methods Ninety children with Hp associated gastritis admitted in pediatrics department in Affiliated People＇s Hospital of Quanzhou Medical College from July 2014 to July 2015 were selected and randomly divided into control group and observation group with 45 cases in each group. Patients in the control group were given standard triple therapy. Patients in the observation group received probiotics treatment on basis of treatment used in the control group. Curative effect,adverse reactions and recurrence in one year follow-up were compared between two groups. Results Total effective rate in the observation group was higher than that in the control group with statistically significant difference（ χ2= 5. 69,P〈 0. 05）. Scores on epigastric pain,abdominal bloating,acid reflux and belching after treatment were lower than before treatment in both groups（ t value ranged 5. 67 to 9. 33,all P〈 0. 05）,and differences in above scores between two groups after treatment had statistic significance（ t value ranged 7. 03 to 8. 11,all P〈 0. 05）. Incidences of nausea,vomiting,dizziness,drowsiness and recurrence in one year follow-up in the observation group were lower compared with those in the control group,and differences were statistically significant（ χ2value was 5. 89,6. 33,6. 25 and 5. 69,respectively,all P〈 0. 05）.Conclusion Triple therapy combined with probiotics treatment has advantages of significant clinical effect and low incidence of adverse reactions in treating Hp associated gastritis in children. No recurrence is found during follow-up.
作者
邹逢佳
苏成安
ZOU Feng-jia SU Cheng-an(Quanzhou Medical College in Fu Jian, Fujian Quanzhou 362000, Chin)
出处
《中国妇幼健康研究》
2017年第7期815-816,835,共3页
Chinese Journal of Woman and Child Health Research
基金
泉州市科技计划重点资助项目(2010Z39)
关键词
三联疗法
益生菌
小儿幽门螺杆菌
胃炎
triple therapy
probiotics
pediatric helicobacter pylori
gastritis
