摘要
目的观察柳氮磺胺吡啶联合康复新液治疗溃疡性结肠炎的临床效果。方法选择2014年5月至2016年5月本院收治的溃疡性结肠炎患者82例作为研究对象,随机分为观察组与对照组,每组各41例。对照组予柳氮磺胺吡啶治疗,观察组在对照组基础上联合康复新液。比较两组治疗前后的血清降钙素原(PCT)、C反应蛋白(CRP)、肠道黏膜核因子(NF)-κB与Toll样受体4(TLR-4)含量、疗效以及不良反应总发生率。结果两组治疗前血清PCT与CRP水平、NF-κB与TLR-4 m RNA含量的差异均无统计学意义(P>0.05);治疗后观察组血清PCT、CRP水平为(0.44±0.10)ng/m L、(14.56±4.20)mg/m L,NF-κB、TLR-4 m RNA含量为(36.54±6.77)、(38.69±5.86),均低于本组治疗前与对照组治疗后同一时点(均P<0.05)。观察组有效率为90.24%,高于对照组的73.17%,差异有统计学意义(P<0.05)。观察组及对照组不良反应总发生率分别为14.63%、9.76%,差异无统计学意义(P>0.05)。结论相比于单用柳氮磺胺吡啶,联用康复新液的治疗方案更利于降低溃疡性结肠炎患者的血清PCT、CRP水平以及肠道黏膜NF-κB及TLR-4的表达,临床疗效更优。
Objective To investigate the effect of sulfasalazine combined with Kangfuxin solution on ulcerative colitis and its effect on NF-κB expression. Methods 82 cases of ulcerative colitis patients were randomly assigned into treatment group and control group,with41 cases in each group. The control group was treated with sulfasalazine,and the treatment group was treated with sulfasalazine combined Kangfuxinye. The levels of serum procalcitonin（PCT）,C reactive protein（CRP）,intestinal mucosal nuclear factor（NF）-kappa B and Toll like receptor 4（TLR-4）,effective rate and incidence of adverse reactions were compared between the two groups before and after treatment. Results There were no difference in serum level of PCT,CRP and m RNA content of NF-kappa B and TLR-4 before treatment in the two groups（P〉0. 05）. The serum level of PCT,CRP and m RNA content of NF-kappa B and TLR-4 in the treatmentgroup after treatment[（0.44±0.10） ng/m L,（14.56±4.20） mg/m L,（36.54±6.77）,（38.69±5.86）,respectively] were lower than those before treatment and in the control groupafter treatment（P〈0. 05）. The effective rate of the treatment group was 90.24%,which was higher than that of the control group（73.17%,P〈0. 05）. The incidence of adverse reactions of the two groups was 14.63% and9.76%,respectively（P〉0. 05）. Conclusion The application of sulfasalazine combined Kangfuxinye in ulcerative colitis can effectively reduce the level of serum PCT and CRP,inhibite the expression of NF-κB in the intestinal mucosa. There is synergistic effect between the two drugs,with high effectiveness and safety.
作者
杨秀薇
杨蓉
Yang Xiuwei Yang Rong.(GI Medicine, People＇s Hospital of Aba Tibetan and Qiang Autonomous Prefecture, ABA, Sichuan, 624000, Chin)
出处
《结直肠肛门外科》
2017年第3期364-367,共4页
Journal of Colorectal & Anal Surgery
