摘要
特发性肺纤维化的核心病机为肺虚络瘀,将通络补络法作为治疗特发性肺纤维化的基本治法,具有一定疗效,其现代医学基础是通过调节转化生长因子β_1(TGF-β_1)介导的传导通路的失衡、抗肺泡上皮细胞过度凋亡、抗氧化应激损伤三个方面,从而延缓特发性肺纤维化的进程。
The core pathogenesis of idiopathic pulmonary fibrosis（ IPF） is lung deficiency and collateral stasis.It is effective to take dredging and supplementing collaterals method as the basic therapy in treating IPF. The modern medicine basis is delaying the course of IPF by 3 aspects： regulating the imbalance of conduction pathway mediated by transforming growth factorβ_1（ TGF-β_1）,anti-excessive apoptosis of alveolar epithelial cells and anti-oxidative stress injury.
作者
刘妍彤
吕晓东
庞立健
刘创
刘勇明
LIU Yantong LYU Xiaodong PANG Lijian LIU Chuang LlU Yongming(First Clinical School, Liaoning University of Traditional Chinese Medicine, Shenyang, 110032 Affiliated Hospital to Liaoning University of Chinese Medicine)
出处
《中医杂志》
CSCD
北大核心
2017年第16期1381-1384,共4页
Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81403290)
沈阳市科技局计划项目(F14-231-1-13)
辽宁省高等学校科学研究一般项目(L2014369)
关键词
特发性肺纤维化
通络补络法
肺虚络瘀
idiopathic pulmonary fibrosis
dredging and supplementing collaterals method
lung deficiency and collateral stasis
