摘要
目的:探讨肾气丸防治肺纤维化作用及机理。方法:用平阳霉素复制肺纤维化模型大鼠后,中药组每天灌胃肾气丸,28d后处死,观察、比较各组大鼠肺部病理组织学改变、肺组织及血清中超氧化物歧化酶(SOD)的活力。结果:模型组大鼠肺泡炎及纤维化程度明显高于正常对照组及中药组,肺组织及血清中SOD活力均明显低于正常对照组及中药组。结论:肾气丸能明显减轻平阳霉素所致的大鼠肺泡炎及纤维化程度,提高肺组织及血清中超氧化物歧化酶(SOD)的活力。
Object:To investigate the effect and mechanism of Jinkuishenqi pill(JGSQ)on pulmonary fibrosis.Methods:Pulmonary fibrosis was induced by bleomycinA5 in SD rats.In drug group JGSQ was given daily for 28 days,and then were sacrified.The lungs of all rats were harrested for histopathological examination.The activity of SOD in lungs and serum were measured and compared.Results:The degree of the alveolitis and pulmonary fibrosis in the model rats were more serious than that of the normal control rats and the rats taking JGSQ.The activity of SOD in lungs and serum from the model rats were significantly lower than those of the normal contral rats and the rats taking JGSQ.Conclusion:JGSQ could significantly alleviate the degree of the alveolitis and pulmonary fibrosis,increase activity of SOD in lungs and serum from the rats with pulmonary fibrosis.
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2005年第6期418-419,424,共3页
JOURNAL OF BASIC CHINESE MEDICINE
基金
河南省教育厅自然科学基金项目(2003360193)
