摘要
目的总结长链非编码RNA(long non-coding RNA,lncRNA)与甲状腺乳头状癌相关性的研究进展。方法复习涉及甲状腺乳头状癌相关lnc RNA的文献,对lnc RNA与甲状腺乳头状癌的关系进行总结。结果 MAP激酶通路和生长抑制相关非编码RNA(NAMA)、甲状腺乳头状癌易感候选基因3(PTCSC3)、BRAF激活的非编码RNA(BANCR)、母系表达基因3(MEG3)、NONHSAT037832、GAS8-AS1等在甲状腺乳头状癌组织中呈低表达。ENST00000537266、ENST00000426615、XLOC051122、XLOC006074、HOX基因的反义基因间RNA(HOTAIR)、INK4位点反义非编码RNA(ANRIL)、转移相关肺腺癌转录本1(MALAT1)等在甲状腺乳头状癌组织中呈高表达。上述lnc RNA可能参与了甲状腺乳头状癌细胞的增殖、侵袭和凋亡。结论 lnc RNA可能为甲状腺乳头状癌发病的分子机制和基因靶向治疗提供新的依据,可能成为诊断甲状腺乳头状癌的新分子指标。
Objective The aim of this study is to review the association between long non-coding RNA （lncRNA） and papillary thyroid carcinoma （PTC）. Method The relevant literatures about lncRNA associated with PTC were retrospectively analyzed and summarized. Results The expression levels of noncoding RNA associated with MAP kinase pathway and growth arrest （NAMA）, PTC susceptibility candidate 3 （PTCSC3）, BRAF activated non-coding RNA （BANCR）, maternally expressed gene 3 （MEG3）, NONHSAT037832, and GAS8-AS1 in PTC tissues were significantly lower than those in non-thyroid carcinoma tissues. The expression levels of ENST00000537266, ENST00000426615, XLOC051122, XLOC006074, HOX transcript antisense RNA （HOTAIR）, antisense noncoding RNA in the INK4 locus （ANRIL）, and metastasis-associated lung adenocarcinoma transcript 1 （MALAT1） in PTC tissues were upregulated in PTC tissues, comparing with the non-thyroid carcinoma tissues. These lncRNAs were possibly involved in cell proliferation, migration, and apoptosis of PTC. Conclusion LncRNAs may provide new insights into the molecular mechanism and gene-targeted therapy of PTC and become new molecular marker for the diagnosis of PTC.
出处
《中国普外基础与临床杂志》
CAS
2017年第8期1030-1034,共5页
Chinese Journal of Bases and Clinics In General Surgery
