摘要
基因的失调控（异常表达）是肿瘤发生发展的重要原因（诱因）业已被学术界所公认,而在这一过程中非编码RNA（non-coding RNA,ncRNA）起到了极为重要的调控作用[1-2]。小RNA（small RNA;包括微小RNA,microRNA,miRNA,miR）和长链非编码RNA（long non-coding RNA,lncRNA）均属于ncRNA[3-4]。
It has been estimated that approximately 75% of the human genome is transcribed into RNA, 74% of which would be transcribed into non-coding RNA （ncRNA）. The ncRNA can be divided into 2 major groups including small RNA and long non-coding RNA （IncRNA）. There is increasing evidence that the dysregulation of IncRNA is closely associated with the occurrence and progression of many tumors. The IncRNA taurine up-regulated gene 1 （ TUG1） is origi-nally detected in a genomic screen for genes in response to taurine treatment of developing mouse retinal cells. According to research reports, dysregulation of TUG1 participates in the progression of a variety of tumors. Therefore, the regulatory effects of IncRNA TUG1 on tumorigenesis are summarized in this article.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2017年第7期1332-1337,共6页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.81602088)
黑龙江省卫生计生委科研课题资助项目(No.2016049)
黑龙江省博士后资助课题(No.LBH-Z16096)
哈尔滨医科大学创新科学研究基金资助项目(No.2016LCZX09)
