摘要
目的分析干扰素对慢性丙肝患者CD_4^+CD_(25)^+Treg细胞及甲状腺功能的影响,为临床治疗提供参考依据。方法选取医院2012年5月-2015年5月收治的80例慢性丙型病毒性肝炎患者,依据随机数表法分成观察组与对照组,各40例;对照组予以常规药物治疗,观察组予以干扰素治疗,观察两组患者治疗后各项指标水平变化及不良反应率。结果治疗后,观察组CD_4^+CD_(25)^+Treg细胞为(7.52±1.10)%、对照组为(8.21±1.13)%,两组比较差异有统计学意义(P<0.05);观察组谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TbiL)、直接胆红素(DbiL)低于对照组(P<0.05);两组不良反应率比较差异无统计学意义。结论干扰素对慢性丙型肝炎患者的治疗效果比较确切,对甲状腺的功能影响较小,能够明显地改善患者的肝功能,降低CD_4^+CD_(25)^+Treg细胞水平,调节机体免疫应答反应,促进患者康复。
OBJECTIVE To analyze the effects of interferon on CD4^＋CD25^＋Treg cells and thyroid function in patients with chronic hepatitis C,so as to provide references for clinical treatment.METHODS A total of 80 cases of patients with chronic hepatitis C from May 2012 to May 2015 were selected,and were divided into observation group and control group according to a random number table method,with each group of 40 cases.Patients in control group received conventional drug therapy,and in observation group received interferon therapy.The change of indexes and adverse reaction rates in the two groups after treatment were observed.RESULTS After treatment,CD4^＋CD25^＋Treg cells of observation group and control group were（7.52±1.10）% and（8.21±1.13）%,and the difference was significant（P〈0.05）.The levels of AST,ALT,TbiL and BbiL of observation group were lower than those of control group.There was no significant difference between the two groups in the rate of adverse reactions.CONCLUSIONThe curative effect of interferon in patients with chronic hepatitis C is exact,its effect on the thyroid function is little,which can significantly improve the patient＇s liver function,reduce the levels of CD4^＋CD25^＋Treg cells,regulate the body＇s immune response,and promote patients recover.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第14期3188-3191,共4页
Chinese Journal of Nosocomiology
