摘要
目的观察中药内服联合外浴治疗奥沙利铂所致蓄积性周围神经毒性的临床疗效。方法将84例应用奥沙利铂化疗发生蓄积性周围神经毒性的患者应用随机数字表法分为治疗组及对照组,每组各42例,治疗组应用中药内服联合外浴治疗,对照组应用维生素B_1及甲钴胺治疗,疗程均为3周。观察两组治疗前后周围神经毒性分级变化、临床疗效及不良反应。结果治疗组治疗后周围神经毒性分级变化分布与治疗前比较,差异有统计学意义(P<0.05),且两组治疗后比较,差异有统计学意义(P<0.05),治疗组能明显改善周围神经毒性程度。两组总有效率比较,差异有统计学意义(P<0.05),治疗组疗效明显优于对照组。两组均未发生明显不良反应。结论中药内服联合外浴治疗奥沙利铂所致蓄积性周围神经毒性具有较好的临床疗效。
Objective To observe clinical efficacy of oral administration and external bath of traditional Chinese medicine （TCM） for cumulative peripheral neurotoxicity induced by oxaliplatin （ OXA）. Methods Eighty-four patients with cumulative peripheral neurotox-icity induced by oxaliplatin were assigned into treatment group and control group according to random number table method （42 cases for each group） . The treatment group was treated with oral administration and external bath of TCM,and the control group was treated with vitamin and mecobalamin. Both courses of treatment lasted for 21 days. Index changes of peripheral neurotoxicity before and af-ter the treatment, clinical efficacy and adverse reactions were observed in the two groups. Results There was statistically significant difference in index change distribution of peripheral neurotoxicity with treatment group after treatment compared with before treatment （P〈0. 05）. And after treatment, the difference was statistically significant between the treatment group and the control group （P 〈 0.05）. The degree of peripheral neurotoxicity could be obviously improved in the treatment group. There was statistically significant difference in total effective rate between the treatment group and the control group （P 〈 0 . 0 5 ） ,and the curative effect of the treatment group was superior to the control group. There were no obvious adverse reactions in the two groups. Conclusions Oral administration and external bath of TCM has better clinical curative effect on cumulative peripheral neurotoxicity induced by oxaliplatin.
出处
《安徽医药》
CAS
2017年第9期1696-1698,共3页
Anhui Medical and Pharmaceutical Journal
关键词
中药
奥沙利铂
周围神经毒性
Traditional Chinese medicine （TCM）
Oxaliplatin
Peripheral neurotoxicity
