摘要
目的研究细胞毒性T淋巴细胞相关抗原4及血管内皮细胞生长因子受体2在乳腺癌中的表达与乳腺癌病理分级的相关性。方法使用免疫组化法检测37例乳腺癌患者癌旁组织以及癌组织中细胞毒性T淋巴细胞相关抗原4及血管内皮细胞生长因子受体2的表达，并分析其表达水平与乳腺癌病理分级的相关性。结果细胞毒性T淋巴细胞相关抗原4在癌间质的T淋巴细胞和乳腺癌细胞中都有表达，在乳腺癌细胞中的表达水平显著高于在癌旁组织，且其表达水平与癌组织级别呈正比。血管内皮细胞生长因子受体2主要在癌旁组织导管的上皮细胞及乳腺癌细胞的胞膜及胞浆中表达，且在乳腺癌的各级别问表达程度随肿瘤的恶性程度的增加而升高。结论细胞毒性T淋巴细胞相关抗原4及血管内皮细胞生长因子受体2表达与乳腺癌的病理分级呈正相关性。
Objective To study the correlation of cytotoxic T-lymphocyte-associated protein 4 （CTLA-4） and Vascular Endothelial Growth Factor Receptor 2 （VEGFR2） expression in breast cancer and the patho- logical grading. Methods Immunohistochemistry was used to detect the expression of CTLA-4 and VEG- FR2 in 37 cases of breast cancer,and the relationship between its expression and the breast tumor pathological grading was analyzed. Results CTLA-4 had expression in both T lymphocyte and breast cancer cell in carcinoma stroma, expression level in breast cancer ceil was obviously higher than in para-carcinoma tis- sue, and its expression level was positively related with cancer level. VEGFR2 mainly expressed in epithelial cell of para-carcinoma tissue duct, cytomemhrane and cytoplasm of breast cancer, and its expression level was increased with the increasing of malignant grade. Conclusion The pathological grading is positively correlated with CTLA-4 and VEGFR2 expression in breast cancer.
出处
《临床心身疾病杂志》
CAS
2017年第4期1-4,共4页
Journal of Clinical Psychosomatic Diseases
基金
国家自然科学基金青年科学基金项目（编号81502023）
