摘要
目的探讨祛风利湿合剂治疗特应性皮炎风湿蕴肤证的临床效果。方法选择2015年9月~2016年2月就诊于上海中医药大学附属曙光医院皮肤科的风湿蕴肤型特应性皮炎患者72例,采用随机数字表法将其分成为试验组和对照组,各36例。试验组口服祛风利湿合剂,每日2次,每次30 mL;对照组口服盐酸西替利嗪,每日1次,每次10 mg。两组患者均外用氯地松乳膏,每日2次。两组疗程均为4周。观察两组治疗前后视觉模拟评分(VAS)、瘙痒时间占夜间睡眠的百分比(PIT)、湿疹面积及严重度指数(EASI)积分的变化和临床疗效。结果两组治疗后VAS评分、PIT值、EASI积分均较治疗前显著降低(P<0.01),且试验组治疗后PIT值、EASI积分显著低于对照组(P<0.01)。试验组和对照组总有效率分别为82.4%、64.5%,差异无统计学意义(P>0.05)。但试验组的愈显率(50.0%)明显高于对照组(22.6%)(P<0.05)。结论祛风利湿合剂治疗特应性皮炎风湿蕴肤证具有较好的临床效果,可明显改善患者的瘙痒程度及皮损情况。
Objective To discuss the clinical efficacy of Qufeng Lishi Mixture in treating fengshi yunfu-type atopic dermatitis. Methods Seventy-two patients with fengshi yunfu-type atopic dermatitis admitted to Department of Dermatology of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from September 2015 to February 2016 were selected and divided into experimental group and control group by random number table method,with 36 cases in each group. The experimental group was treated with oral adminstration of 30 mL Qufeng Lishi Mixture,twice a day; the control group was treated with oral adminstration of 10 mg Cetirizine Hydrochloride, once a day. Both groups were given Chloramphenicol Dexamethasone Cream for external use, twice a day. The course of the two groups was both 4 weeks. The changes of visual analogue scale（VAS）, the percent of itching time（PIT）, eczema area and severity index（EASI） integral before and after the treatment and the clinical efficacy in the two groups were observed. Results After treatment, the VAS score, PIT value and EASI integral in two groups were all lower than those before treatment（P〈0.01）. The PIT value and EASI integral in the experimental group after treatment were lower than those of control group（P〈0.01）. The total effective rate of experimental group and control group was 82.4% and 64.5% respectively, but there was no statistically significant difference between the two groups（P〈0.05）. The cured and markedly effective rate of experimental group（50.0%） was significantly higher than that of control group（22.6%）（P〈0.05）. Conclusion Qufeng Lishi Mixture in the treatment of fengshi yunfu-type atopic dermatitis has good clinical efficacy, which can significantly improve the degree of pruritus and skin lesions.
作者
李星子
徐平
潘卫东
张慧敏
LI Xingzi XU Ping PAN Weidong ZHANG Huimin(Department of Dermatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Department of Internal Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China)
出处
《中国医药导报》
CAS
2017年第22期101-104,共4页
China Medical Herald
基金
上海市浦东新区中医药事业发展专项资金项目(PDYNZJ2015-29)
关键词
特应性皮炎
风湿蕴肤证
祛风利湿合剂
Atopic dermatitis
Fengshi yunfu-type
Qufeng Lishi Mixture
