摘要
从白喉乌头(Aconitum leucostomum Vorosch.)中分离得到13个二萜生物碱,采用HR-ESI-MS,1D NMR和2D NMR等波谱技术确定了它们的结构.其中一个为新的C_(18)二萜生物碱:刺乌宁,其余为已知化合物.同时考察了其中12个化合物对甜菜夜蛾3龄幼虫的拒食活性,结果表明化合物氨茴酰基牛扁碱和东乌头定的活性较好(EC_(50)<1mg/cm^2),其次是N-acetylsepaconitine,赣乌碱和N-去乙酰高乌甲素(EC_(50)<2 mg/cm^2).
A new C18 diterpenoid alkaloid, leucostonine（1）, was isolated from the whole plant of Aconitum leucostomum Vorosch., together with twelve known diterpenoid alkaloids. Their structures were elucidated on the basis of extensive spectroscopic analysis, including HR-ESI-MS, 1D NMR and 2D NMR spectra. 12 compounds were tested for their antifeedant activity against larvae of Spodoptera exigua Hiibner. Anthranoyllycoctonine and avadharidine showed considerable potent antifeedant activity（EC50〈1 mg/cm2）, followed by N-acetylsepaconitine, finaconitine and N-deacetylappaconitine（EC50〈2 mg/cm2）.
作者
陈琳
王倩
黄帅
单连海
高峰
周先礼
Chen Lin Wang Qian Huang Shuai Shan Lianhai Gao Feng Zhou Xianli(School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031 School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031 School of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2017年第7期1839-1843,共5页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.81402803)
四川省小分子天然药物创新团队(No.15TD0048)
四川省教育厅项目(No.15ZB0140)
中央高校基本科研业务费专项(No.2682017QY04)资助项目~~
