摘要
目的 研究氨茶碱应用于胸外科围手术期患者的临床疗效。方法 选取230例胸外科手术患者为研究对象,随机分为研究组和对照组,每组115例患者。对照组患者手术过程中实施胸腔闭式引流,持续至术后3 d,并于术后12 h予以患者乳酸环丙沙星注射液静脉滴注,持续治疗7 d;在对照组治疗的基础上,研究组患者于麻醉诱导后开始,予以静脉注射氨茶碱,持续治疗3天,检测2组患者手术前后肺部及呼吸道炎症相关因子水平（白细胞、PCT、hs-CRP、TNF-α、IL-6、IL-8和IL-10）和血气指标,观察并发症和药物不良反应情况。结果 术后24 h研究组患者白细胞、PCT、hs-CRP、TNF-α、IL-6、IL-8水平显著低于对照组患者（P〈0.05）,IL-10水平显著高于对照组患者（P〈0.05）;术后24h研究组患者动脉氧分压（PaO2）显著高于对照组患者水平（P〈0.05）,2组患者术后动脉二氧化碳分压（PaCO2）均显著低于术前水平（P〈0.05）;术后10 d内研究组患者并发症发生率显著低于对照组患者（P〈0.05）,且2组患者均未出现药物不良反应。结论 在胸外科围手术期对患者予以氨茶碱干预治疗,可以有效改善患者预后。
Objective To investigate the therapeutic effect of aminophylline on the treatment of patients with thoracic surgery perioperative. Methods 230 cases with thoracic surgery were selected as the research objects and divided into the research group and the control group randomly, and there was 15 cases in each group. the control group were ginven closed drainage of thoracic cavity during the surgery, continued to 3 days after surgery. The control group were given intravenous drip of ciprofloxacin lactate injection at 12 h after operation, and the treatment lasted for 7 days. At this basis, the research group were given aminophylline 0.5 mg/d by intravenous injection at the beginning of anesthesia induction and continued for 3 days. The levels of lung and respiratory inflammation related factor （White blood cells, PCT, hs-CRP, TNF-α, IL-6, IL-8 and IL-10）, blood gas index in the two groups pre- and post–surgery were detected, and the complications and adverse drug reactions were observed. Results 24h after surgery, TNF alpha, IL-6, IL-8 were significantly lower than those in the control group （P〈0.05）, and IL-10 level was significantly higher than that in the control group （P〈0.05）. And PaO2 in the research groupwas significantly higher than that in the control group patients （P〈0.05）. After treatment, arterial carbon dioxide partial pressure （PaCO2） in the two groups were significantly lower than preoperative （P〈0.05）. The complication rate in the research group was significantly lower than that in the control group within ten days（P〈0.05）. There were no adverse reactions in both groups. Conclusion During the perioperative period in thoracic surgery, aminophylline intervention can effectively improve the prognosis. .
出处
《中国生化药物杂志》
CAS
2017年第8期113-116,共4页
Chinese Journal of Biochemical Pharmaceutics
关键词
胸外科手术
氨茶碱
围手术期
thoracic surgeries
aminophylline
perioperative
