摘要
目的：探讨单唾液酸神经节苷脂注射液在新生儿缺氧缺血性脑病治疗过程中的临床疗效以及应用价值。方法：选择2014年7月～2016年7月期间在湖北江汉油田总医院住院治疗的84例缺氧缺血性脑病新生儿患儿，按照随机原则分为两组，其中对照组给予常规的治疗，而观察组患儿则在给予常规治疗的同时加用单唾液酸神经节苷脂注射液治疗，对比两组患儿的疗效，采用神经行为测定法（NBNA）评估两组得分、基质金属蛋白酶-9（MMP-9）的水平。结果：对照组总有效32例（76％），观察组总有效40例（95％），差异有统计学意义（P〈0．05）。两组患儿在治疗后NBNA评分均出现了一定程度的升高，和治疗前相比差异显著（P〈0．05），组间对比发现观察组患儿的NBNA评分升高程度要明显优于对照组，差异有统计学意义（P〈0．05）。对照组及观察组患儿治疗前的MMP-9水平分别是19．8（±3．5）μg／L和20．1（±3．4）μg／L，差异无统计学意义（P〉0．05），在治疗后则分别是14．9（±3．3）vg／L、10．2（±2．9）μg／L，差异有统计学意义（P〈0．05）。结论：对于新生儿缺氧缺血性脑病的患儿，可以在原有治疗基础上加用单唾液酸神经节苷脂注射液，可以显著提高治疗效果，同时还可以有效改善神经行为，帮助患儿早日康复。
Objective：To discuss the clinical effect and application of single sialic acid ganglioside injection in the treatment of neonatal hypoxic ischemic encephalopathy. Methods：84 cases of infants with neonatal hypoxic ischemic encephalopathy in our hospital from July 2014 to July 2016 were selected and randomly divided into two groups. The control group was given routine treatment, while the observation group was given single sialic acid ganglioside injection. The effect of both groups were compared by eval- uating the NBNA and MMP-9 levels of both qroups. Results： According to the effects of different treatments, the total effective rate of the control group was 76.2 % （32/42）, while the observation groups was 95.2%（40/42）. The difference was significant（P〈0.05）. The NBNA scores of both groups were im- proved after treatment, with significant difference （P〈0.05）. The improvement of NBNA scores in the observation group was significantly better than that of the control group. The difference was significant （P〈0.05）. Before treatment, the MMP-9 scores of the control group and observation group were 19.8 （±3.5） μg/L and 20. 1（±3.4） μg/L. The difference was not significant（P〉0.05）. After treatment, the MMP-9 scores were 14.9（±3.3） μg/L and 10.2（±2.9） μg/L. The difference was significant（P〈 0.05）. Conclusion：In the treatment of infantile neonatal hypoxic ischemic encephalopathy, the single sialic acid gangtisoside injection on the basis of routine treatment can effectively improve the treatment and im- prove the neurobehavior for earlier recovery.
出处
《癫痫与神经电生理学杂志》
2017年第4期219-222,共4页
Journal of Epileptology and Electroneurophysiology(China)
