摘要
目的:探讨难治性高血压(RH)患者并发心脑血管疾病的危险因素。方法:回顾性分析2010年6月至2015年7月我院收治的536例RH患者的临床资料。根据是否合并有心脑血管疾病,患者被分为合并症组(217例)和单纯RH组(319例)。结果:与单纯RH组比较,并发症组饮酒史、吸烟史、高血压病程、平均动脉压(MAP)、平均收缩压、脉压、血尿酸、肌酐、总胆固醇和低密度脂蛋白-胆固醇(LDL-C)水平均显著升高,高密度脂蛋白-胆固醇、平均舒张压和平均心率显著降低(P均<0.01)。多因素非条件Logistic回归分析显示高血压病程、MAP、肌酐、血尿酸及LDL-C水平为RH合并心脑血管疾病的独立危险因素(OR=1.014~3.217,P<0.05或<0.01)。结论:高血压病程、MAP、肌酐、血尿酸、LDL-C等为难治性高血压的独立危险因素,加强其监测和防治,对于降低心脑血管疾病并发症的发生率有重要意义。
Objective： To explore risk factors for complicated cardiovascular and cerebrovascular diseases in patients with refractory hypertension （RH）. Methods： Clinical data of 536 RH patients, who were treated in our hospital from Jun 2010 to Jul 2015, were retrospectively analyzed. According to presence of cardiovascular and cerebrovascu- lar diseases or not, patients were divided into complication group （n = 217） and pure RH group （n = 319）. Results： Compared with pure RH group, there were significant rise in percentages of drinking and smoking, hypertension course, mean arterial pressure （MAP）, mean systolic blood pressure, pulse pressure, serum uric acid （SUA）, creati- nine （Cr）, total cholesterol and low density lipoprotein cholesterol （LDL-C）, and significant reductions in high den- sity lipoprotein cholesterol （HDL-C） mean diastolic blood pressure and mean heart rate in complication group, P〈 0.01 all. Multi-factor unconditional Logistic regression analysis indicated that hypertension course, SUA, MAP, Cr and LDL-C levels were independent risk factors for complicated cardiovascular and cerebrovascular diseases in RH patients （OR= 1.014-3. 217, P〈0.05 or 〈0.01）. Conclusion： Hypertension course, MAP, Cr, SUA and LDL- C are independent risk factors for refractory hypertension. Enhancing their monitor, prevention and treatment are important to reduce incidence rates of cardiovascular and cerebrovascular complications in patients with refractory hypertension.
作者
朱科
陈先华
宋洁
刘灵
ZHU Ke CHEN Xian-hua SONG Jie LIU Ling(Department of Preventive Care, Southwest Hospital of Third Military Medical University, Chongqing, 400039, Chin)
出处
《心血管康复医学杂志》
CAS
2017年第3期324-327,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
高血压
心血管疾病
脑血管障碍
危险因素
Hypertension
Cardiovascular disease
Cerebrovascular disorders
Risk factors
