摘要
目的:探讨住院患者心源性猝死(SCD)发生的影响因素。方法:临床纳入因心脏病死亡的患者124例,根据是否为SCD分为SCD组(65例)与非SCD组(59例)。比较两组患者临床资料、实验室检测结果、死亡时生物节律以及心电图表现等。结果:死亡时生物节律方面,SCD组发生在6:01~12:00比例为41.54%,显著高于其它时段(P均<0.01);非SCD组各时段差异则无显著性(P>0.05)。与非SCD组比较,SCD组在6:01~12:00时段死亡的比例(23.73%比41.54%,P=0.007)明显升高,SCD组肌酸激酶[CK,(1140.66±176.63)IU/L比(1949.52±2141.22)IU/L]、肌酸激酶同工酶[CK-MB,(92.43±28.30)IU/L比(175.20±231.44)IU/L]、心肌肌钙蛋白I[cTnI,(30.09±34.27)mg/L比(44.34±10.60)mg/L]水平明显升高,左室射血分数[LVEF,(49.83±11.24)%比(37.53±23.11)%]明显降低(P均<0.01);在SCD组中,冠心病导致的SCD占86.15%(56/65),其中心肌梗死占66.15%(43/65)。结论:冠心病特别是心肌梗死是临床引发心源性猝死的重要因素。检测CK、CK-MB、cTnI及LVEF水平对防治心源性猝死有重要意义。
Objective： To explore influencing factors for sudden cardiac death （SCD） in inpatients. Methods： A total of 124 patients died of heart disease were enrolled. According to SCD or not, they were divided into SCD group （n = 65） and non-SCD group （n = 59）. Clinical data, laboratory examination results, biological rhythm and ECG manifestation at death were compared between two groups. Results： For biological rhythm at death, 41.54% death occurred during 6： 01-12.. 00 in SCD group, which was significantly higher than other time period （P〈0.01 all）; there was no significant difference in mortality among all time periods in non-SCD group （P〉 0.05）. Compared with non-SCD group, there were significant rise in death proportion in 6： 01-12：00 （23.73% vs. 41.54%, P= 0. 007）, in levels of creatine kinase FCK, （1140.66 ± 176.63） IU/L vs. （1949.52 ± 2141.22） IU/L], creatine kinase isoenzyme MB [CK-MB, （92.43 ± 28.30） IU/L vs. （175.20 ± 231.44） IU/L] and cardiac troponin I [cTnI, （30.09 ± 34. 27） mg/L vs. （44. 34 ± 10.60） mg/L], and significant reduction in left ventricular ejection fraction [LVEF, （49.83 ± 11.24）% vs. （37.53 ± 23.11） % ] in SCD group, P〈0.01 all; in SCD group, SCD caused by coronary heart disease occupied 86.15% （56/65）, and myocardial infarction occupied 66. 15% （43/65）. Conclusion.. Coronary heart disease, especially myocardial infarction, is an important factor leading to sudden cardiac death . Detection of CK, CK-MB, cTnI and LVEF levels have important sense for prevention and treatment of sudden cardiac death.
作者
张宇
ZHANG Yu(Department of Cardiology, People＇s Hospital of Meizhou City, Meizhou, Gnangdong, 514031, China)
出处
《心血管康复医学杂志》
CAS
2017年第3期261-264,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
猝死
心脏
冠心病
心肌梗死
Death, sudden, cardiac
Coronary disease
Myocardial infarction
