摘要
目的:观察滋肾疏肝、清热养血法治疗帕金森病的临床疗效。方法:将80例帕金森病患者随机分为两组,对照组予以普拉克索治疗,治疗组在对照组基础上加滋肾疏肝、清热养血法治疗,2个月为1个疗程,共治疗1个疗程。观察两组患者统一帕金森病评定量表(unified parkinson disease rating scale,UPDRS)评分、Webster评分、匹兹堡睡眠质量指数量表(pittsburgh sleep quality index,PSQI)评分情况,检测睡眠的连续性及稳定性,利用蒙特利尔认知评估量表(montreal cognitive assessment,Mo CA)评定认知功能,比较BECK焦虑量表(beck anxiety inventory,BAI)评分及BECK抑郁量表(beck depression inventory,BDI)评分,测定血清pentraxin-3水平及RANTES水平。结果:两组患者治疗后UPDRS评分及Webster评分均显著降低,且治疗组优于对照组,差异有统计学意义(P<0.01);治疗组有效率为92.5%,对照组有效率为80.0%,两组比较,差异有统计学意义(P<0.05);治疗后两组患者PSQI评分均显著降低(P<0.01),且治疗组优于对照组(P<0.01);治疗组睡眠连续性及稳定性检测优于对照组(P<0.01);两组均能显著提高患者的Mo CA各项因子评分(P<0.01),且治疗组提高更明显(P<0.01);治疗后治疗组BAI评分和BDI评分均较对照组下降明显,两组比较,差异有统计学意义(P<0.01);两组均能显著降低血清pentraxin-3水平及RANTES水平,且治疗组显著优于对照(P<0.01)。结论:以肾疏肝、清热养血法为指导治疗帕金森病能明显改善患者的临床症状,提高睡眠质量、认知功能,改善抑郁、焦虑等精神状况,改善患者预后。
Objective：To observe the curative effect of TCM Zishen Shugan and Qingre Yangxue method in treatment of Parkinson＇s disease.Methods：80 patients with Parkinson＇s disease were randomly divided into two groups.The control group was treated with pramipexole.The treatment group was treated with traditional Chinese medicine on the basis of that of the control group.The treatment group was treated with 1 course of treatment for 2 months.The values of the unified Parkinson＇s disease rating scale（UP-DRS）,the Webster score,the Pittsburgh sleep quality index（PSQI）score,the continuity and stability of the sleep were measured.The Monterey Cognitive Assessment（MoC A）to determine the cognitive function.The beck anxiety inventory（BAI）score and the beck depression inventory score（BDI）were observed.The Serum pentraxin-3 levels and RANTES levels was compared.Results：The UPDRS score and Webster score were significantly lower in the two groups,and that of the treatment group was significantly lower than that of the control group（P〈0.01）.The effective rate of the treatment group was 92.5%and that of the control group was 80.0%,and that of the treatment group was superior to that of the control group（P〈0.01）.There was a significant differ- ence between the two groups in the continuity and stability of the sleep,with that of the treatment group being better（P〈0.01）.The scores of MoC A were higher than those before treatment,and the treatment group was significantly higher than that of the control group（P〈0.01）.The BAI score and BDI score of both groups were lower and that of the treatment group was significantly lower than that of the control group（P〈0.01）.The levels of serum pentraxin-3 and RANTES were lower in the two groups and that of the treatment group was significant lower than that of the control group（P〈0.01）.Conclusion：TCM Zishen Shugan and Qingre Yangxue method in treatment of Parkinson＇s disease with Chinese herbal medicine can improve the clinical sympt
作者
古春青
金杰
GU Chunqing JIN Jie(The First Affiliated Hospital to Henan University of Chinese Medicine, Henan Zhengzhou China 45000)
出处
《中医学报》
CAS
2017年第7期1257-1261,共5页
Acta Chinese Medicine
基金
河南省中医药科学研究专项(2013ZY02028)
关键词
帕金森病
滋肾疏肝、清热养血法
普拉克索
中医药治疗
中西医结合
Parkinson＇s disease
TCM Zishen Shugan and Qingre Yangxue method
Pramaxo
Chinese medicine treatment
combine traditional Chinese and western medicine
