摘要
目的:评价奥美拉唑治疗新生儿应激性溃疡的临床疗效和安全性。方法:本研究采用随机平行对照试验研究设计方案,将80例应激性溃疡新生儿受试者随机分为试验组和对照组各40例。试验组给予奥美拉唑胃管注入,0.6 mg/kg,1次/日,连续使用5 d。对照组给予去甲肾上腺素胃管注入,0.4 mg去甲肾上腺素加入生理盐水10 m L,每6 h 1次,连续使用5 d。两组均维持治疗直至胃回抽物不再有咖啡样液体或鲜红色的液体后,然后再行治疗1 d。疗效及安全性的评定采用总有效率、主要临床症状消失时间,胃液p H变化及不良反应发生情况。结果:治疗后,试验组患儿的总有效率为87.5%,对照组为47.5%,两组比较差异有统计学意义(P<0.01);试验组的主要临床症状消失时间短于对照组,差异有统计学意义(P<0.05);试验组患儿胃液p H为6.76±1.25,对照组为5.51±1.13,两组比较差异有统计学意义(P<0.05)。两组均未见明显不良反应(P>0.05)。结论:奥美拉唑胃管注入治疗新生儿应激性溃疡疗效优于去甲肾上腺素,两组均未见明显不良反应。
Objective： To assess the effectiveness and safety of omeprazole for treating neonates with stress ulcer. Methods： This study was designed as a randomized parallel control trial. Eighty neonates were randomly divided into the intervention group（ 40 cases） and the control group（ 40 cases）. Neonates in the control group were received norepinephrine 0. 4 mg ＋ normal saline 10 m L injected into the stomach,once every 6 hours for 5 days,while the cases in the intervention group were received omeprazole injection,0. 6 mg/kg,once daily for 5 days,until no coffee-like liquid material to be found in the stomach and then continued for an additional day treatment.The outcomes include total effective rate,disappearance time of main symptoms,p H of gastric fluid and adverse reactions. Results：After treatment,the total effective rate was 87. 5% in the intervention group and 47. 5% in control group respectively,there was significant difference between two groups（ P〈0. 01）. The disappearance time of main symptoms was much shorter in the intervention than that in the control group（ P〈0. 05）. The p H of gastric fluid was 6. 76±1. 25 in the intervention group,while it was 5. 51±1. 13 in the control group,the significant difference was found between two groups（ P〈0. 05）. There was no obvious adverse reactions in two groups. Conclusion： Omeprazole is superior to the norepinephrine for treating neonates with stress ulcer,there is no obvious adverse reaction in two groups.
作者
张粉霞
刘荣
宜雄雄
Zhang Fenxia Liu Rong Yi Xiongxiong(Yan＇ an People＇s Hospital of Shaanxi Province, Shaanxi Yan＇ an 716000, China)
出处
《儿科药学杂志》
CAS
2017年第8期23-26,共4页
Journal of Pediatric Pharmacy
