摘要
目的评价持续小剂量微泵滴注奥美拉唑治疗新生儿应激性溃疡的临床疗效和安全性。方法将82例应激性溃疡新生儿分为对照组40例与试验组42例。对照组予以奥美拉唑0.8 mg·kg-1·d-1,每天1次,连续使用3 d;试验组给予奥美拉唑2 mg·kg-1,24 h持续微泵滴注治疗。比较2组患者的临床疗效、治疗前后胃液p H值及不良反应发生率。结果治疗后,试验组的总有效率为92.86%,对照组为87.50%(P>0.05),但试验组显效率(52.38%)显著高于对照组(27.50%,P<0.05)。治疗后,2组p H值水平均显著高于治疗前(P<0.05),且试验组治疗后p H值显著高于对照组(P<0.05)。2组治疗过程中均未见药物相关不良反应发生。结论持续微泵滴注奥美拉唑治疗新生儿应激性溃疡的临床疗效显著,优于常规给药方式。
Objective To investigate the clinical efficacy and safety of continuous intravenous infusion of low dosage omeprazole for the treat- ment of neonatal stress ulcer. Methods Eighty - two chihtren with neo- natal stress ulcer included in this study were randomly divided into con- trol group（n = 40） and treatment group （ n = 42）. All of the included cases were given ambrosia, gastrolavage, antibiotic, and hemostasis basic treatment. And cases in the control group were also given omeprazole 0. 8 mg kg-1 . d-1 intravenous transfusion qd with 3 days. Subjects in the treatment group were given omeprazole 2 mg kg-1 intravenous transfu- sion for 24 hours. After treatment, the clinical efficacy, pH of gastric fluid and drug related toxicity were compared between the two groups. Results After treatment, the clinical efficacy were 92.86% and 87.50% in the treatment and control group respectively with no signifi- cant difference （P 〉 0.05 ）. But the excellence rate were 52.38% and 27.50% with treatment group statistical higher than control group （P 〉0. 05）. After treatment, the pH value of the two groups all increased than before treatment （P 〈 0. 05）, and the treatment group were much higher than control group（P 〈0. 05）. No obvious drug related toxicity was observed in the two groups. Conclusion It is effective and safe for continuous intravenous infusion of low dosage omeprazole in the treatment of neonatal stress ulcer which was superior to regular administration.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第18期1812-1814,共3页
The Chinese Journal of Clinical Pharmacology
