摘要
目的对中晚期宫颈癌同步放化疗中的TP(紫杉醇+奈达铂)与DF(奈达铂+氟尿嘧啶)两种方案进行对比研究,探索更合理的化疗方案及给药周期。方法按化疗方案的不同将62例拟行宫颈癌同步放化疗的患者,随机分为TP组(31例)与DF组(31例),对两组免疫指标、生存率及毒副反应进行对比研究。结果治疗后1个月两组患者CD3+、CD4+水平及CD4+/CD8+比值较治疗前均明显降低(t分别=3.21、4.61、5.68、4.36、5.35、7.12,P均<0.05),而两组NK细胞水平较治疗前明显升高(t分别=4.31、5.61,P均<0.05)。TP组总有效率与DF组比较,差异无统计学意义(χ~2=0.92,P>0.05)。TP组中位生存时间49.11月,DF组中位生存时间43.11月。TP组5年生存率61.33%,DF组5年生存率58.21%。两组5年生存率比较,差异无统计学意义(χ~2=0.91,P>0.05)。TP组骨髓抑制Ⅰ度、Ⅱ度发生率均高于DF组,差异具有统计学意义(χ~2分别=4.78、5.43,P均<0.05),但两组患者消化道反应比较,差异无统计学意义(χ~2分别=0.24、0.48,P均>0.05)。结论中晚期宫颈癌同步放化疗TP方案在骨髓抑制发生率上优于DF方案。
Objective To compare the effects of the TP and DF chemotherapys in concurrent chemoradiotherapy on the patients with advanced cervical cancer. Methods Totally 62 cases with advanced cervical cancer were selected and divided into the TP group and the DF group. Immune parameters,survival rate and side effects of two groups were observed.Results After 1 month of treatment,the levels of CD^3＋,CD^4＋,and CD^4＋/CD^8＋ ratio of two groups were significantly lower than before treatment（t=3.21,4.61,5.68,4.36,5.35,7.12,P〈0.05）,while the NK level of two groups significantly higher than before treatment（t=4.31,5.61,P〈0.05）. There was not statistically difference in total effective rate of two groups（χ^2=0.92,P〉0.05）. An average survived time of TP group was 49.11 months,and the DF group was 43.11 months. A 5-year survival rate of TP group was 61.33%,and the DF group was 58.21%. The difference between two groups was not significant（χ^2=0.91,P〉0.05）. The incidence of bone marrow suppression degrees of the TP group was significantly higher than that of the DF group（χ^2=4.78,5.43,P〈0.05）. The difference in gastrointestinal reaction of two groups had not reached statistical significance（χ^2=0.24,0.48,P〉0.05）. Conclusion TP chemotherapy is superior to the DF chemotherapy in the incidence of bone marrow suppression for advanced cervical cancer patients in concurrent chemoradiotherapy.
作者
叶鸿
王宝强
吴爱菊
YE Hong WANG Baoqiang WU Aiju.(Department of Radiotherapy, The People＇s Hospital of Lishui City, Lishui 323000,China)
出处
《全科医学临床与教育》
2017年第4期380-383,共4页
Clinical Education of General Practice
关键词
宫颈癌
放化疗同步治疗
化疗
生存率
cervix cancer
concurrent chemoradiotherapy
chemotherapy
survival rate
