摘要
目的对沈阳市2006—2010年3种主要大气污染物(SO_2、NO_2、PM10)与总出生缺陷及前5顺位疾病进行统计分析,探讨各种大气污染物与出生缺陷各病种之间的关联。方法应用描述性研究方法,分地区和季节等分析3种大气污染物及总出生缺陷及前5顺位出生缺陷检出率;应用生态学研究方法,分析3种大气污染与出生缺陷及前5顺位的关联性。结果沈阳市2006—2010年3种大气污染物不同地区、季度差异有统计学意义(P<0.05);不同地区总出生缺陷、先心病、总唇腭裂、外耳其他畸形检出率差异有统计学意义(P<0.05),不同季度总出生缺陷、先心病、总唇腭裂、血管瘤检出率差异有统计学意义(P<0.05);按总出生缺陷检出率地区别分组,3种大气污染物差异有统计学意义(P<0.05),季节别分组差异有统计学意义(P<0.05),Spearman相关分析发现PM10浓度与先天性心脏病及血管瘤具有相关性(r=0.810、0.714),NO_2与血管瘤也具有相关性(r=0.771)。结论沈阳地区3种大气污染物与总出生缺陷及前5顺位出生缺陷的发生在地区和季节间存在一定的相关性。
Objective To analyze monitoring data of major air pollutants （sulfur dioxide[SO2],nitrogen dioxide[NO2],particulate mater less than 10 μm in aerodynamic diameter[P10]） and total and major birth defects in Shenyang from 2006 to 2010,and to explore relationships between various air pollutants and the incidences of birth defects for providing evidences to researches on environmental etiology of birth defects. Methods Concentrations of the three major air pollutants and detection rates of total birth defects and main types the defects in Shenyang city were analyzed with descriptive methods.Ecological methodology was adopted to explore relationships between air pollutant concentrations and incidents of birth defects. Results During the five year period,there were significantly regional differences in the ambient air concentrations of SO2,NO2,and PM10（F=149.54,93.39,and 205.69,P〈0.05 for all） and there were also significantly seasonal differences in the ambient air concentrations of SO2,NO2,and PM10（F=2 035.74,638.10,and 287.41,P〈0.05 for all）.The concentrations of the three major air pollutants were positively correlated with each other （r=0.517,0.464,and 0.396）.There were significant regional differences in detection rates of total birth defect,congenital heart disease,total cleft lip and palate,and other malformations of the external ear （χ2=30.58,14.78,26.74,and 37.25,P〈0.05 for all）.There were significant seasonal differences in total birth defects,congenital heart disease,total cleft palate,and hemangioma （χ2=240.88,47.44,12.83,and 30.92,P〈0.05 for all）.The concentrations of the three major air pollutants differed significantly by regions with the highest and the lowest total birth defect detection rate （t=19.36,21.66,and 17.02,P〈0.05 for all）,and by seasons with higher and lower total birth defect detection rate （t=58.50,41.05,and 27.54,P〈0.05 for all）.The resulats of Spearman correlation analysis revealed tha PM10 concentration was associated with detection rates o
出处
《中国公共卫生》
CAS
CSCD
北大核心
2017年第7期1129-1131,共3页
Chinese Journal of Public Health
基金
辽宁省科技计划项目(2015225025)
辽宁省科学事业公益研究基金资助项目(201500100)
沈阳市科技计划项目(F15-139-9-09)
关键词
大气污染物
出生缺陷
检出率
atmospheric pollution
birth defects
detection rate
