摘要
目的:对失代偿期丙型肝炎肝硬化患者抗病毒治疗进行观察分析。方法:选择138例失代偿期丙型肝炎肝硬化患者作为研究对象,随机分为研究组和对照组,每组各69例。研究组患者手术后予以抗病毒治疗,对照组则不予以抗病毒治疗。对比抗病毒治疗后的临床疗效。结果:研究组患者在进行手术治疗后,血小板和WBC的计数明显升高,Child-Pugh评分也明显下降,均符合抗病毒治疗的评分标准;研究组实施抗病毒48周的后,1年中平均住院次数研究组明显低于对照组,P<0.05;研究组Child-Pugh的评分明显低于对照组,P<0.05;研究组患者在持续病毒学的应答率、ALT的复常率都较对照组明显增高,P<0.05;研究组在进行治疗的过程中均出现不良反应,结束治疗后均消失。结论:运用抗病毒对失代偿期丙型肝炎肝硬化的术后患者进行治疗时,患者持续病毒学的应答率、ALT的复常率均较高,临床效果显著,值得推广。
Objective： To observe and analyze the antiviral therapy for patients with decompensated hepatitis C cirrhosis（ HCV）. Methods： 138 cases with decompensated HCV were selected as the subjects and divided into experimental group（ n = 69）and control group（ n = 69）. After the surgery,the experimental group was given the antiviral therapy,while the control group was given nothing. Then,the clinical effects of the two groups were compared. Results： After the surgical treatment,the platelet count and WBC of the experimental group patients significantly increased and the Child-Pugh score decreased significantly,which all met the standard of the antiviral therapy. Then,the experimental groupwas given the antiviral therapy for 48 weeks. The average hospitalization times in a year and the Child-Pugh score of the experimental group were significantly less than those of the control group（ P〈0.05）; however,the sustained virological response rate and ALT recovery rate were significantly higher than those of the control group（ P〈0.05）. Further,some adverse reactions occurred in the process of the treatment,but they all disappearedafter the end of the treatment. Conclusions： For the patients with decompensated HCV after the surgery,the antiviral therapy could improve the sustained virological response rate and the ALT recurrence rate,has significant clinical effects and is worthy of promotion.
出处
《中国民康医学》
2017年第10期20-22,共3页
Medical Journal of Chinese People’s Health
关键词
丙型肝炎
肝硬化
抗病毒治疗
Hepatitis C virus
Liver cirrhosis
Antiviral therapy
