摘要
目的探讨糖尿病肾病合并高血压患者接受氨氯地平、缬沙坦单独治疗和联合治疗的临床效果,以及患者肾功能受到的影响,分析血压、尿微量蛋白等指标。方法选取2016年2月—2017年2月该院的63例糖尿病肾病合并高血压患者来分析,将患者分成3组,均有21例,A组使用氨氯地平治疗,B组使用缬沙坦治疗,C组使用氨氯地平和缬沙坦联合治疗。结果 3组患者的血压均显著降低,C组降低的幅度比AB两组均要大,结果差异有统计学意义(P<0.05)。经过16周的治疗,患者的24 h尿蛋白水平比治疗前有所改善,C组的尿蛋白降低幅度比AB两组均要高(P<0.05)。经过治疗,3组患者的Scr、BUN检测显示,肌酐、尿胆素水平差异无统计学意义(P>0.05)。结论氨氯地平、缬沙坦单独治疗糖尿病肾病合并高血压疾病的效果不及两者联合治疗的效果,而且还能够保护肾功能,降低尿蛋白排出。
Objective To discuss the clinical effect of single hypotensor and combined medication of amlodipine and valsar- tan in treatment of type 2 diabetic nephropathy and hypertension and effect on the renal function and analyze the indexes of blood pressure and microalbuminuria. Methods From February 2016 to February 2017,63 cases of patients with diabetic nephropathy and hypertension admitted and treated in our hospital were divided into three groups with 21 cases in each, the group A were treated with amlodipine, the group B were treated with valsartan, and the group C were treated with amlodipine and valsartan. Results The blood pressure of the three groups obviously decreased, and the decrease range in the group C was bigger than that in the group A and in the group B, and the difference was statistically significant （P〈0.05）, after 16-week treatment, the 24-hour proteinuria of patients were improved compared with that before treatment, and the decrease range of urine protein in the group C was higher than that in the group A and group B （P〈0.05）, after treatment, the Sc and rBUN tests showed that the difference was not statistically significant in the creatinine and urchin levels （P〉 0.05）. Condusion The effect of the combined medication of amlodipine and valsartan in treatment of diabetic nephropathy and hypertension is better than that of the single medication, and it can protect the renal function and reduce the urine protein excretion.
出处
《糖尿病新世界》
2017年第8期93-94,共2页
Diabetes New World Magazine
关键词
氨氯地平
缬沙坦
糖尿病肾病
高血压
尿蛋白
Amlodipine
Valsartan
Diabetic nephropathy
Hypertension
Urine protein
