摘要
目的:研究血小板衍生生长因子-BB(PDGF-BB)浓度与冠状动脉支架内再狭窄(ISR)的关系,评估其对预测冠状动脉支架内再狭窄的作用。方法:选取280例行冠状动脉植入支架的患者,测定术前及术后1 d,术后1个月,术后3个月,术后6个月,术后12个月的血浆和尿PDGF-BB浓度,根据术后12个月冠脉造影结果分为三组:阴性组(原支架通畅)、阳性1组(原支架狭窄<50%或支架内轻度内膜增生)、阳性2组(ISR组,原支架再狭窄≥50%以上),分析各组血浆、尿PDGF-BB浓度差异,比较其与冠状动脉支架内再狭窄的相关性。结果:三组患者年龄、性别构成比均无统计学差异(P>0.05);三组患者高血压、糖尿病、吸烟、血脂、身体质量指数(BMI)指标均无明显差异;阳性1组、阳性2组(ISR组)血浆、尿液PDGF-BB浓度明显高于阴性组(P<0.01),且具有统计学差异;阳性1组术前血浆、尿液PDGF-BB浓度低于阳性2组(ISR组)(P<0.05),其中血浆浓度降低更明显(P<0.01),术后第1 d起阳性1组血液、尿液PDGF-BB浓度显著低于阳性2组(P<0.01);血浆、尿PDGF-BB浓度相关系数r=0.857,其显著性<0.001,说明在置信度为0.01时,血浆与尿PDGF-BB浓度的相关性显著;随访中三组患者血浆与尿PDGF-BB浓度均在术后1天最高,后缓慢下降;阴性组患者术后第12月血浆与尿PDGF-BB浓度均可降至术前水平,但阳性1组与阳性2组(ISR组)患者术后第12月血浆与尿PDGF-BB浓度较术前稍有升高。结论:冠状动脉支架内再狭窄患者无论血浆还是尿液中的PDGF-BB浓度均高于轻度再狭窄和未狭窄患者,提示PDGF-BB有预测冠状动脉支架内再狭窄的作用。
Objective： To study the relationship between platelet-derived growth factor-BB（ PDGF-BB）concentration and in-stent restenosis in coronary artery,and to evaluate its effect on in-stent restenosis. Methods：280 patients undergoing coronary artery stent implantation were selected. The concentrations of PDG-BB in plasma and urine were measured before operation,1st day,1st month,3rdmonth,6th month and 12 thmonth after operation.The patients were divided into three groups according to the results of coronary angiography 12 months after operation,the positive group（ the original stent was unobstructed）,the positive group 1（ the original stent stenosis 50% or stent mild intimal hyperplasia）,the positive group 2（ ISR,the original stent restenosis ≥50%）. the concentrations of PDGF-BB in plasma and urine were analyzed and compared with those of coronary stent restenosis. Results： There was no statistically significant difference in age and sex ratio（ P〉0. 05）. There were no significant differences in hypertension,diabetes mellitus,smoking,blood lipid and BMI among the three groups. The concentration of PDGF-BB in plasma and urine of positive group 1 and positive group 2（ ISR group）was significantly higher than that of negative group（ P〈0. 01）,and there was a significant difference. The concentration of PDGF-BB in plasma and urine was lower in positive group1 than that in positive group 2（ ISR group）（ P〈0. 05）,plasma concentration decreased more significantly（ P〈0. 01）,the concentration of PDGF-BB in the blood and urine in the positive group 1 was significantly lower than that in the positive group 2（ ISR group）from the first day after operation.（ P〈0. 01）. The plasma and urine PDGF-BB concentration correlation coefficient was r = 0. 857,the significance 0. 001,indicating that the confidence level of 0. 01,the plasma and urine PDGF-BB concentration was significantly correlated. The concentrations of PDGF-BB in plasma and urine in the three groups were all decre
出处
《现代医学》
2017年第6期766-770,共5页
Modern Medical Journal
基金
上海交通大学医学院自然科学研究基金转化医学研究项目:15ZH1004
