摘要
目的:研究TCT联合HC2-HPV-DNA在宫颈病变诊断中的意义。方法:收集湖南省妇幼保健院怀疑宫颈病变的女性187例,行阴道镜检测,用宫颈拭子获取脱落细胞进行HC2-HPV-DNA和TCT检测,同时进行病理学活检。以病理诊断结果为金标准,计算TCT、HC2-HPV-DNA及两者联合检测筛查宫颈病变的敏感度、特异度、假阳性率、假阴性率和诊断符合率,评价其诊断价值。结果:HC2-HPV-DNA对宫颈病变的筛查敏感性高于HPV E6/E7mRNA TCT检测(分别为83.61%及75.41%),但其特异度明显低于后者(分别为52.38%及74.60%),两种检测均存在较高的假阳性率(25.40%及47.62%),两者联合检测可提高诊断的特异度(81.95%)及诊断符合率(78.07%)。结论:TCT和HC2-HPA-DNA联合检测可提高特异度及诊断符合率,在妇女宫宫颈病变筛查中具有较高的应用价值。
Objective To research the application of the TCT and HC2-HPV-DNA in cervical lesions screening project.Methods The test results of TCT and HC2-HPV-DNA of 187 cases were used and compared. Based on the pathologydiagnosis,specificity and sensitivity of these two screening methods were calculated. Results HC2 had hisher sensitivity(83.61%) and lower specificity(52.38%) than TCT(75.41% and 74.60%) respectively.Both of them had high false positive rates,HC2 25.7% and TCT 45.7%.Co-test of these two methods increased the specificity to 81.95% and the consistency rate to 72.13%.There were no significant differences amongfalse negative rates of TCT,HC2 and CO-test.Conclusion In the cervical lesions screening of women, TCT and HC2 co-test decreased the false positive rate and increased thespecificity and diagnosis coincidence rate.The co-test method was valuable in the cervical lesions screening of women.
出处
《湖南师范大学学报（医学版）》
2012年第4期51-54,共4页
Journal of Hunan Normal University(Medical Sciences)
