摘要
目的探讨自然周期排卵后血清孕酮(P)测定对决定冷冻胚胎移植(FET)时机的作用。方法回顾性分析587周期自然周期FET患者,排卵后按首日P≥10 nmol/L(称P上升)的排卵天数分组,D0组:排卵日P上升,31周期;D1组:排卵后1 d P上升,357周期;D2组:排卵后2 d P上升,199周期。P上升1 d移植第2天卵裂期胚胎;P上升2 d移植第3天胚胎。比较3组患者一般状况及胚胎移植结局。结果 3组患者年龄、不孕时间、基础卵泡刺激素(FSH)、移植日子宫内膜厚度、移植胚胎数、优质胚胎数比较差异无统计学意义(均P>0.05);D0组胚胎种植率显著高于D1组,分别为40.98%、23.95%;D0组妊娠率显著高于D1组及D2组,分别为64.52%、36.97%、40.20%;D2组与D1组相比胚胎种植率及妊娠率有增高的趋势,差异无统计学意义(P>0.05)。流产率各组比较差异无统计学意义(P>0.05)。结论结合B超测排卵,监测P上升,有助于确定自然周期冻胚移植日,使部分患者胚胎移植提前或后移1天进行,提高妊娠率。
Objective To explore the effect of serum progesterone measurement after ovulation in determining opportunity of natural cycle frozen-thawed embryo transfer（FET）.Methods A total of 587 natural cycle FET patients were analyzed retrospectively,then they were divided into different groups according to the ovulation days when serum progesterone concentration≥10 nmol/L for the first time：D0group（serum progesterone concentration increased on the day of ovulation,31 cycles）,D1 group（serum progesterone concentration increased at one day after ovulation,357 cycles）,and D2 group（serum progesterone concentration increased at two days after ovulation,199 cycles）.FET was performed one day after increase of serum progesterone concentration for cleavage stage embryos on the second day,and two days after increase of serum progesterone concentration for embryos on the third day.The general situations and embryo transfer outcomes in the three groups were compared.Results There was no statistically significant difference in age,duration of infertility,basic follicle-stimulating hormone（FSH）,endometrial thickness on the day of embryo transfer,the number of transferred embryos,and the number of high-quality embryos among the three groups（all P〈0.05）;the embryo implantation rate in D0 group was 40.98%,which was significantly higher than that in D1 group（23.95%）.The pregnancy rate in D0 group was 64.52%,which was significantly higher than those in D1 group and D2 group（36.97% and 40.20%,respectively）.Compared with D1 group,the embryo implantation rate and pregnancy rate in D2 group showed an increasing trend,but there was no statistically significant difference（P〈0.05）.There was no statistically significant difference in abortion rate among different groups（P〈0.05）.Conclusion Ovulation monitoring by ultrasonography and increase of serum progesterone level can contribute to determine opportunity of natural cycle FET,embryo transfer before and after one day may improve pregnancy rate among
出处
《中国妇幼保健》
CAS
2017年第13期2991-2993,共3页
Maternal and Child Health Care of China
关键词
冷冻胚胎移植
自然周期
孕酮
妊娠率
Frozen-thawed embryo transfer
Natural cycle
Progesterone
Pregnancy rate
