摘要
目的探讨IVF患者注射HCG日与注射前两日血清孕酮(P)持续高水平对妊娠结局的影响。方法回顾性分析1 520例体外受精-胚胎移植周期患者的临床资料,根据HCG注射日及前两日的血清P水平将患者分成3组,A组:3日P均≤2.93nmol/L(n=1 128),B组:任意两日P>2.93nmol/L(n=307),C组:连续3日P>2.93nmol/L(n=85),比较各组间移植后14d血HCG阳性率、临床妊娠率、继续妊娠率和妊娠丢失率。结果 C组移植后14dHCG阳性率(41.18%)较另两组(A组67.55%、B组62.21%)显著下降,而A、B、C3组间临床妊娠率(44.59%vs.42.02%vs.36.47%)、继续妊娠率(37.50%vs.37.13%vs.29.41%)及妊娠丢失率(44.49%vs.40.31%vs.28.57%)比较,差异无统计学意义(P>0.05)。结论晚卵泡期P持续高水平可能影响胚胎着床,但对临床妊娠率和妊娠维持的影响并不明显。
Objective： To explore the influence of continuously high serum progesterone（P）levels from two days before HCG injection to HCG day on pregnancy outcome. Methods： The clinical data of 1 520 patients undergone IVF/ICSI were retrospectively analyzed. The patients were divided into three groups according to the serum Plevels from two days before HCG injection to HCG day：group A consisted of patients with P〈2.93 nmol/L in all three days（n= 1 128）group B consisted of patients with P〈2.93 nmol/L in any two days（n=307）and group C consisted of patients with P〉2.93 nmol/L in all the three continuous days（n= 85）. The biochemical pregnancy rate, clinical pregnancy rate, ongoing pregnancy rate and pregnancy loss rate were compared among the three groups. Results： The rate of biochemical pregnancy rate was significantly higher in group C（41.18%）than that in group A（67.55%）and group B（62.2%）（P〈0.05）. There were no significant differences in clinical pregnancy rate, ongoing pregnancy rate and pregnancy loss rate among the three groups（P〉0.05）. Conclusions： Continuously high progesterone level during the late follicular phase affects embryos implantation, but not clinical and ongoing pregnancy.
出处
《生殖医学杂志》
CAS
2015年第7期563-566,共4页
Journal of Reproductive Medicine
关键词
晚卵泡期
孕酮水平
临床妊娠
妊娠丢失
Late follicular phase
Progesterone level
Clinical pregnancy
Pregnancy loss
