摘要
G蛋白偶联受体(GPCR)是一类7次跨膜蛋白,广泛表达于人体多个器官和组织,在人体发育和多种生理过程中发挥重要作用,并且与多种疾病的发生紧密相关。因此,开发针对GPCR蛋白的药物是医药领域长期以来的一个研究方向。在药物研发方面,单克隆抗体因靶向性好、副作用小等特点,越来越受到人们重视,已成功应用到多种疾病的治疗中。综述GPCR蛋白相关作用机制和抗GPCR抗体的研发情况,旨在为GPCR蛋白研究和抗体药物研发提供思路。
G protein-coupled receptors （GPCRs） are a superfamily of seven-transmembrane proteins with wide expression in various organs and tissues. They play significant roles in the development and many physiological processes of human body and are closely related to pathogenesis of many diseases. Therefore, development of drugs targeting GPCR proteins has long been an important trend in pharmaceutical field. From the perspective of drug development, therapeutic monoclonal antibodies are attractive options due to their accurate targeting, less side effect, and wide application in the treatment of multiple diseases. In this article, GPCR-relatod mechanisms and current situation of research and development of therapeutic anti-GPCR antibody were reviewed, so as to inspire researchers to generate new ideas in this field.
出处
《药学进展》
CAS
2017年第6期419-426,共8页
Progress in Pharmaceutical Sciences
关键词
G蛋白偶联受体
抗体药物
信号通路
新药研发
G protein-coupled receptor
antibody drug
signaling pathway
new drug R＆D
