摘要
目的探讨2型糖尿病(T2DM)患者与骨质疏松(osteo porosis,OP)的相关性。方法选取2015年9月~2017年2月我院收治的180例2型糖尿病患者,将90例2型糖尿病患者血糖控制达标设为A组;另外90例2型糖尿病患者空腹(血糖≥7.0mmoL/L)及餐后2小时血糖(血糖≥10.0mmoL/L)均升高为B组。另选择我院同期健康体检者90例作为对照组,采用美国GDR-2000型Hologac Sahara超声骨密度仪测量跟骨骨密度。测定全部受试者均测量身高、体重,计算体重指数(BMI)。过夜空腹12h以上,次日晨采静脉血,检测糖化血红蛋白(HbAlc)、血磷、尿钙、血钙、血镁、甲状旁腺激素(PTH)、25羟维生素D_3(25(OH)D_3)及碱性磷酸酶(ALP)等临床生化指标。结果 A组尿钙、血钙、血镁、PTH、25(OH)D_3等指标与对照组比较差异有统计学意义(P<0.05);B组尿钙、血钙、血镁、PTH、25(OH)D_3、ALP等指标与对照组比较差异有统计学意义(P<0.05);B组尿钙明显高于A组,而血镁、25(OH)D_3、ALP等指标明显低于A组,且比较差异有统计学意义(P<0.05);骨质疏松组患者HbAlc、PTH、糖尿病病程等指标均明显高于骨量减低组和骨密度正常组,且比较差异军有统计学意义(P<0.05);病程、HbAlc、PTH是糖尿病患者骨密度降低的危险因素。结论血糖控制未达标T2DM患者骨密度水平低于血糖控制达标2型糖尿病患者,T2DM与OP二者有相关性。病程、HbAlc、PTH是影响T2DM患者骨密度水平的因素。
Objective To investigate the correlation between osteoporosis（OP） and type 2 diabetes mellitus （T2DM）. Methods 180 patients with type 2 diabetes mellitus in our hospital from January 2015 to February 2017 were selected.90 patients with type 2 diabetes mellitus were divided into group A,and 90 patients with type 2 diabetes with fasting（blood glucose ≥ 7.0mmol/L） and 2 hours postprandial blood glucose （blood glucose ≥10.0mmol/L） were divided into group B.And 90 cases of healthy physical examination in our hospital were selected as the control group.The bone mineral density of calcaneus was measured by American GDR-2000 Hologac Sahara Ultrasound Bone Minimetry.All subjects were measured for height,body weight,and body mass index （BMI）.（HbA1c）,blood phosphorus,urinary calcium,serum calcium,blood magnesium,parathyroid hormone（PTH）,25-hydroxy vitamin D3（25（OH）D3） were measured on the morning fasting for more than 12 hours.And alkaline phosphatase（ALP） and other clinical biochemical indicators. Results The levels of urinary calcium,serum calcium,magnesium,PTH and 25（OH） D3 in group A were significantly higher than those in control group（P 〈0.05）.The levels of urinary calcium, serum calcium, magnesium,PTH,25（OH）D3 and ALP in group B were significantly lower than those in the control group（P 〈0.05）.The urinary calcium in group B was significantly higher than that in group A（P 〈 0.05）.The BMD of the femoral neck in group B was significantly lower than that in group A（P 〈 0.05）.The osteoporosis group had higher HbAlc and PTH than the control group（P 〈 0.05）.The course of disease,HbAlc and PTH were the risk factors of bone mineral density decrease in diabetic patients. Conclusion The level of bone mineral density in T2DM patients is lower than that in patients with type 2 diabetes mellitus.There is correlation between T2DM and OP.Course of disease,HbAic,PTH are factors affecting the level of bone mineral density in T2DM patients.
出处
《中国医药科学》
2017年第12期192-195,共4页
China Medicine And Pharmacy
基金
广东省东莞市科技计划医疗卫生类科研一般项目(2015105101075)
关键词
2型糖尿病
骨质疏松
骨密度
Type 2 diabetes
Osteoporosis
Bone mineral density
