摘要
目的探讨骨转换生化标志物在原发性肾病综合征(PNS)肾性骨营养不良的早期诊断价值。方法检测30例PNS患者(PNS组)与50例健康体检者(对照组)血清中骨转换生化标志物总Ⅰ型前胶原氨基端延长肽(TPⅠNP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTx)、完整甲状旁腺素(iPTH)及血清钙(Ca)、血清磷(P)、碱性磷酸酶(ALP)、25羟维生素D3[25-(OH)VD3]等相关生化指标之间的差异。结果 PNS组TPⅠNP、β-CTx、iPTH、ALP、Cr及Bun较对照组显著升高(P<0.01或P<0.05),Ca、25-(OH)VD3较对照组显著降低(均P<0.05);TPⅠNP与β-CTx、iPTH、ALP、Cr、Bun呈正相关(P<0.01或P<0.05),与Ca、25-(OH)VD3呈负相关(均P<0.01);β-CTx与iPTH、ALP、Cr、Bun呈正相关(P<0.01或P<0.05),与Ca、25-(OH)VD3呈负相关(均P<0.01)。结论联合检测TPⅠNP、β-CTx可提高对PNS患者并发肾性骨营养不良的早期诊断率。
ABSTRACT:Objective To explore the value of biochemical markers of bone turnover in early di-agnosis of renal osteodystrophy in patients with primary nephrotic syndrome(PNS).Methods The levels of total procollagen type Ⅰ amino-terminal propeptide of(TPⅠNP),β-isomerized car-boxyterminal propeptide(β-CTx),intact parathyroid hormone(iPTH),calcium(Ca),phosphorus (P),alkaline phosphatase(ALP),25-OH vitamin D3 ,creatinine(Cr)and blood urea nitrogen(Bun) in serum were measured in 30 PNS patients(PNS group)and 50 healthy subjects(control group). Results Compared with control group,levels of TPⅠ NP,β-CTx,iPTH,ALP,Cr and Bun in-creased,but levels of Ca and 25-OH vitamin D3 decreased in PNS group(P <0.01 or P <0.05). The levels of TPⅠNP were positively correlated with the levels of β-CTx,iPTH,ALP,Cr and Bun,but negatively correlated with the levels of Ca and 25-OH vitamin D3 (P < 0.01 or P <0.05).The levels ofβ-CTx were positively correlated with the levels of iPTH,ALP,Cr and Bun, but negatively correlated with Ca and 25-OH vitamin D3 (P < 0.01 or P < 0.05).Conclusion Combined detection of(TPⅠNP)andβ-CTx can improve the early diagnosis of renal osteodystro-phy in patients with PNS.
出处
《实用临床医学（江西）》
CAS
2015年第3期4-6,共3页
Practical Clinical Medicine
