摘要
采用反溶剂法,以肉桂醛为芯材,乙基纤维素(EC)为壁材制备肉桂醛微胶囊,研究了不同芯壁比对微胶囊包埋率及形貌的影响;采用扫描电镜对所得微胶囊的表面形貌进行观察,借助红外光谱和热重分析等对其形成机理能进行了分析,并对其缓释性进行了测试。结果表明,当芯壁比为1∶3时包埋率最大,达到83%,载药量为21%,微胶囊为分散性好、粒径200 nm^1μm的球形粒子。红外光谱、热重分析结果表明EC可以通过自组装将肉桂醛包裹于其形成的疏水性空腔内部。微胶囊存放7 d后,其中的肉桂醛释放率仅为23%,而肉桂醛混合物中肉桂醛的释放率达到了54%,表明肉桂醛微胶囊具有一定缓释性。
Microcapsules were prepared using ethyl cellulose（EC） as wall materials and cinnamaldehyde as core via simple anti-solvent method. The influence of ration of core to wall on encapsulation rate and morphology of microcapsules was studied by SEM, FT-IR and TGA. And the release properties of cinnamaldehyde were evaluated. The results show that at the optimal ratio of core to wall of 1：3, the obtained microcapsules possess high monodisperse spherical shape, have the size ranging from 200 nm-1 μm, and the cinnamaldehyde-loading ratio of 21% and the encapsulation efficiency of 83 %. The results of FT-IR and TGA demonstrate that cinnamaldehyde is successfully entrapped with EC in its hydrophobic cavity formed by self-assembly. The results of storage experiment show that the release ratio of the microcapsules is 23% only after 7 d stored, whereas that of the mixture of cinnamaldehyde and EC is 54 %, which indicate that the obtained mierocapsules have slow-releasing property.
出处
《高分子材料科学与工程》
EI
CAS
CSCD
北大核心
2017年第7期121-125,共5页
Polymer Materials Science & Engineering
基金
国家"973"预研项目(2014CB260411)
陕西科技大学学术带头人团队项目(2013XSD19)
关键词
肉桂醛
乙基纤维素
微胶囊
反溶剂法
cinnamaldehyde
ethyl cellulose
microcapsule
anti-solvent method
