摘要
微波消融作为一种微创治疗技术，不仅通过高温直接灭活肿瘤，还能诱导产生特异性抗肿瘤免疫，成为杀灭肿瘤细胞的新途径。联合免疫治疗可以进一步增强微波消融的抗肿瘤免疫反应，对肿瘤原发灶和转移灶均能产生更强的抑制作用，从而降低肿瘤的复发转移。因此，联合微波消融与免疫治疗为实体肿瘤特别是进展期肿瘤的治疗提供了新思路。本文将就微波消融免疫效应的机制和应用的研究进展进行综述。
Microwave ablation, as a minimally invasive therapy, causes focal hyperthermic injury to ablated tumors. It also induces anti-tumor immunity which could contribute to another mechanism of tumor destruction. Combination with immunotherapy could further enhance the tumor-specific immunity, lead to stronger inhibitory effects on both primary and metastatic lesions and decrease recurrence and metastasis. Thus, combination of microwave ablation and immunotherapy is a promising approach in the treatment of solid tumors, especially for advanced cancers. This article reviews recent advances in the mechanism and application of immune effect induced by microwave ablation.
出处
《国际外科学杂志》
2017年第6期429-432,共4页
International Journal of Surgery
关键词
微波
消融技术
肿瘤
免疫
抗原
肿瘤
Microwaves
Ablation techniques
Neoplasms
Immunity
Antigens, neoplasm
