摘要
目的:观察交泰丸加减方对心肾综合征进展期患者心肾功能的改善作用。方法:60例心肾综合征进展期患者根据完全随机设计原则分为治疗组和对照组,在规范的西药治疗基础上,治疗组加用交泰丸加减,疗程14 d,观察气喘、水肿、尿少等主要中医症状、心功能、肾功能变化,评价药物疗效。结果:与对照组比较,治疗组患者治疗后症状总积分明显减少(P<0.05);中医证候改善优于对照组(P<0.05)。与治疗前比较,两组治疗后纽约心脏病协会(NYHA)心功能分级显著改善(P<0.01);治疗组疗后B型脑钠肽前体(NT-proBNP)显著下降(P<0.01),与对照组比较,治疗组NT-proBNP下降显著(P<0.01);与对照组比较,治疗组治疗后尿素氮(BUN)明显下降(P<0.05)。与治疗前比较,两组治疗后血胱氨酸蛋白酶抑制物-C(Cys-C)均明显下降(P<0.05),治疗组下降显著(P<0.01),与对照组比较,治疗组Cys-C下降明显(P<0.05)。结论:交泰丸加减方能改善心肾综合征进展期患者心肾功能恶化。
Objective： To observe the therapy effect of Jiaotaiwan adding and subtraction prescription on the function of heart and kidney of patients with advanced cardiorenal syndrome （CRS）. Method： The 60 cases patients with CRS were randomly divided into treatment group and control group. The patients in treatment group were treated with Jiaotaiwan adding and subtraction decoction based on routine western medicine. The treatment course was 14 days in both groups, and then the main traditional Chinese medicine （TCM） symptoms such as asthma, edema, and oliguria, as well as heart and kidney functions of patients were observed and the curative effect was evaluated in both groups. Result： The total symptom score of patients in treatment group was decreased and had significant difference as compared with control group （P 〈 0.05） ; the improvement in TCM syndrome in treatment group was better than that of control group （P 〈 0.05）. New York Heart Association （NYHA） cardiac functional grading was improved after treatment in both groups （P 〈 0.01 ）. The level of NT-probrain natriureticpeptide （NT-proBNP） in treatment group was obviously decreased after treatment （P 〈 0.01 ）, and that of the decrease was more obvious in treatment group as compared with that in control group （P 〈 0.01 ）. The level of blood urea nitrogen （BUN） in treatment group was lower than that of control group （P 〈 0.05 ）. The level of cystatin-C （Cys-C） was decreased in both groups after treatment （P 〈 0.05, P 〈 0.01 ） , and the decrease was more obvious in treatment group as compared with that in control group （P 〈 0.05 ）. Conclusion： Jiaotaiwan adding and subtraction decoction can improve the functional deterioration of heart and kidney for patients in the advanced stage of cardiorenal syndrome.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2017年第14期183-187,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81470185)
关键词
心肾综合征
交泰丸
B型脑钠肽前体
血胱氨酸蛋白酶抑制物-C
尿素氮
eardiorenal syndrome
Jiaotaiwan
NT-probrain natriuretic peptide （NT-proBNP）
eystatin- C （Cys-C）
blood urea nitrogen （BUN）
