摘要
目的探讨和分析玉林市儿童新的和严重的药品不良反应(ADR)发生的特点和规律,以提高儿童用药的安全性。方法收集2015~2016年玉林市各医疗机构上报国家药品不良反应监测中心的新的和严重的儿童ADR共402例,对ADR报告进行统计分析并评价。结果 >3~6岁儿童患者新的和严重的ADR发生率较高,共112例(27.86%);引发ADR的给药途径以静脉滴注途径为主,共326例(81.09%);引发新的和严重的ADR药物种类主要是抗肿瘤药物(43.53%),其次是中药及其提取物(18.41%);ADR累及器官或系统主要为血液系统,共167例(41.54%)。结论医疗机构应重点监测儿童用药过程中抗肿瘤药物、中药及其提取物制剂诱发的ADR,加强对儿童患者的用药监护,以提高儿童用药的安全性。
Objective To investigate and analyze the characteristics and patterns of new and/or severe adverse drug reactions（ADR）of children in Yulin,and in order to promote the safety of clinical drug use.Methods Totally 402 new and severe ADR cases of children were collected by National ADR Monitoring Center from 2015 to 2016in Yulin,and those children ADR cases were retrospectively analyzed and evaluated by Excel and artificial screening.Results Among the totally 402 new and severe ADR cases,112 patients aged from 〉3 to 6years old children accounted for 27.86%.Intravenous injection was the most common ADR-inducing route of administration,a total of 326 cases accounted for 81.09%.The new and severe ADR were mainly caused by antitumor drugs（43.53%）,and traditional Chinese medicine extracts and injections（18.41%）.The most common symptoms of organs or systems involved in ADR were lesion of the blood system（41.54%）.Conclusion The monitoring of ADR induced by antitumor and traditional Chinese medicine extract and injection should be strengthened in medical institutions.Clinic drug use monitoring and rational drug use in children should be enhanced and promoted.
出处
《西北药学杂志》
CAS
2017年第4期518-521,共4页
Northwest Pharmaceutical Journal
基金
广西玉林市科技局立项课题项目(编号:玉市科攻13071006)
