摘要
目的:研究不同血清钙水平对终末期肾脏病维持性血液透析患者血管钙化及心血管原因死亡的影响。方法:选取行规律血液透析治疗的终末期肾脏病患者160例,根据血钙水平将入选患者分为3组:低血清钙组(2.0 mmol/L<Ca<2.25 mmol/L)、正常血清钙组(2.25 mmol/L≤Ca≤2.75 mmol/L)、高血清钙组(Ca>2.75 mmol/L)。采用X线摄片评价血管钙化的情况,记录患者临床资料。随访24个月,观察24个月内3组患者发生心血管事件的情况,记录患者因心血管原因死亡的发生时间。Kaplan-Meier生存分析法计算患者生存率。结果:最终有147例患者完成研究,年龄(57.76±13.43)岁,男性72例(48.9%)。患者血管钙化程度与血清钙水平呈正相关。3组患者发生心血管事件的差异有统计学意义(P<0.05)。Kaplan-Meier生存分析法显示:3组患者在心血管原因死亡率(P=0.012)上差异有统计学意义,血钙水平越高,生存率越低。结论:血清钙水平在一定程度上可影响终末期肾脏病维持性血液透析患者血管钙化及心血管原因死亡率。
Objective： To investigate the correlation between serum calcium and the vascular calcification and cardiovascular mortality in patients with end-stage renal disease （ESRD）. Methods： Clinical data of 160 cases of ESRD patients with regular hemodialysis were included. All cases were divided into three groups based on the serum calcium level： lower than normal （2.0 mmol/L〈Ca〈2.25 mmol/L）, normal（2.25 mmol/L≤Ca≤2.75 mmol/L）, higher than normal （Ca 〉2.75 mmol/L）. All the clinical data including age, gender, serum calcium, vascular calcification rate and cardiac event occurrence rate were recorded. The vascular calcification was measured using X-rays. And the cardiac event occurrence rates in two years of all cases with different serum calcium levels were recorded. Kaplan-Meier methods were used to compute the survival rate. Results： There were 147 patients enrolled in the study at last, with a mean age of （57.76±13.43） years old, and 72 of them were male （48.9%）. The degree of vascular calcification and serum calcium levels were positively correlated. The occurrences of cardiovascular event for the three groups had significance differences （P〈0.05）. The cardiovascular mortalities in 24 months for the three groups had significance differences（P=0.012）. Conclusion： The level of serum calcium may influence the vascular calcification and cardiovascular mortality in end-stage renal disease patients to some degree.
作者
杨洁
魏芳
王立华
于海波
卢志
王喆
姜埃利
YANG Jie WEI Fang WANG Li-hua YU Hai-bo LU Zhi WANG Zhe JIANG Ai-li(Blood Purification Division of Nephrology, The Second Hospital , Tianjin Medical University, Tianjin 300211, China)
出处
《天津医科大学学报》
2017年第4期320-323,共4页
Journal of Tianjin Medical University
基金
天津医科大学科研基金资助项目(2015KYZQ15)
关键词
血清钙水平
血管钙化
终末期肾脏病
死亡率
serum calcium
vascular calcification
end-stage renal disease
mortality
